Document Detail

Oral microbiota associated with hyposalivation of different origins.
MedLine Citation:
PMID:  12588452     Owner:  NLM     Status:  MEDLINE    
We analysed and compared the oral microbial flora in four groups with hyposalivation caused by radiation therapy (RT), primary Sjögren's syndrome (pSS), medication or unknown factors (Unknown), or neuroleptic treatment (Neuro). A control group with normal salivary secretion was also included. The subjects included were 54 +/- 8 years old and had 25 +/- 4 teeth. We analysed their microflora in rinsing samples using a cultivation technique. A marked increase in Lactobacillus spp. and Candida albicans was characteristic of the RT group. In the pSS group, 85% of subjects had high numbers of mutans streptococci despite good oral hygiene, frequent dental visits and fluoride use. The Unknown group had an oral flora similar to that of the controls. In the Neuro group, with a stimulated secretion rate similar to that of the Unknown group, the numbers of aciduric and acidogenic microorganisms were close to those in the pSS group. The results indicate that changes in the oral microflora associated with hyposalivation are related to the reason for the hyposalivation rather than to the magnitude of the decrease in the salivary secretion rate.
A AlmståhI; M Wikström; I Stenberg; A Jakobsson; B Fagerberg-Mohlin
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Oral microbiology and immunology     Volume:  18     ISSN:  0902-0055     ISO Abbreviation:  Oral Microbiol. Immunol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-17     Completed Date:  2003-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707451     Medline TA:  Oral Microbiol Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  D    
Department of Oral Microbiology, Institute of Odontology, Hospital Dental Clinic, Vasa Hospital, Göteborg, Sweden.
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MeSH Terms
Analysis of Variance
Antipsychotic Agents / adverse effects
Candida albicans / isolation & purification
Colony Count, Microbial
Cranial Irradiation / adverse effects
Lactobacillus / isolation & purification
Middle Aged
Sjogren's Syndrome / complications
Statistics, Nonparametric
Streptococcus mutans / isolation & purification
Xerostomia / etiology,  microbiology*
Reg. No./Substance:
0/Antipsychotic Agents

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