Document Detail

Oral metronidazole treatment of lichen planus.
MedLine Citation:
PMID:  10906648     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oral metronidazole has been reported to be effective in some patients with idiopathic lichen planus (LP) who did not have concomitant protozoal infections of the intestinal or genital tracts. OBJECTIVE: Our purpose was to evaluate the efficacy of this drug in the treatment of generalized LP. METHODS: Nineteen patients with LP who were free from intestinal and genital protozoal infections were treated with oral metronidazole, 500 mg twice daily, for 20 to 60 days and were followed up for a period of 5 to 36 months. RESULTS: Fifteen patients (78.9%) improved with metronidazole treatment. Complete response was observed in 13 patients (7 women and 6 men). Two patients responded partially. Worsening of the lesions was observed in 1 of the 4 nonresponding patients. CONCLUSION: Metronidazole may be an alternative therapy for the treatment of generalized LP. Its immunomodulatory activity seems to be a possible mechanism of action besides its antimicrobial activity.
A Y Büyük; M Kavala
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  43     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-12     Completed Date:  2000-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  260-2     Citation Subset:  IM    
Division of Dermatology, SSK Göztepe Educational Hospital, IStanbul, Turkey.
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MeSH Terms
Administration, Oral
Lichen Planus / drug therapy*
Metronidazole / administration & dosage*
Middle Aged
Reg. No./Substance:

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