| Oral methotrexate for treatment of ectopic pregnancy. | |
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MedLine Citation:
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PMID: 12066097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate oral methotrexate tablets in the treatment of ectopic pregnancy. STUDY DESIGN: Patients with a diagnosis of ectopic pregnancy were offered oral methotrexate tablets rather that intramuscular injection. Oral methotrexate was given in 2 divided doses 2 hours apart at a dose of 60 mg/m(2) with standard 2.5 mg methotrexate tablets. Patients were followed up with the use of the same protocol that was used typically for intramuscular methotrexate. RESULTS: Nineteen of 22 patients (86%) were successfully treated. There was no statistical difference between patients who were treated successfully or unsuccessfully, with respect to initial human chorionic gonadotropin titers (P =.55), ectopic size (P =.77), or methotrexate dose (P =.18). Nineteen of 22 patients (86%) had increased pain during treatment. Outside of pain, gastrointestinal side effects were the most common. Thirty-two percent of patients required more than one treatment cycle. CONCLUSION: Oral methotrexate can be used to treat ectopic pregnancy successfully, but there are few advantages to recommend its use over intramuscular methotrexate. |
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Authors:
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Gary H Lipscomb; Norman L Meyer; Darby E Flynn; Matt Peterson; Frank W Ling |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 186 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-14 Completed Date: 2002-07-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1192-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage*,
adverse effects,
therapeutic use Administration, Oral Adult Chorionic Gonadotropin / blood Dose-Response Relationship, Drug Drug Administration Schedule Female Gastrointestinal Diseases / chemically induced Humans Methotrexate / administration & dosage*, adverse effects, therapeutic use Pain / chemically induced Pregnancy Pregnancy, Ectopic / blood, drug therapy*, ultrasonography Retreatment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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