Document Detail

Oral methotrexate for treatment of ectopic pregnancy.
MedLine Citation:
PMID:  12066097     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate oral methotrexate tablets in the treatment of ectopic pregnancy. STUDY DESIGN: Patients with a diagnosis of ectopic pregnancy were offered oral methotrexate tablets rather that intramuscular injection. Oral methotrexate was given in 2 divided doses 2 hours apart at a dose of 60 mg/m(2) with standard 2.5 mg methotrexate tablets. Patients were followed up with the use of the same protocol that was used typically for intramuscular methotrexate. RESULTS: Nineteen of 22 patients (86%) were successfully treated. There was no statistical difference between patients who were treated successfully or unsuccessfully, with respect to initial human chorionic gonadotropin titers (P =.55), ectopic size (P =.77), or methotrexate dose (P =.18). Nineteen of 22 patients (86%) had increased pain during treatment. Outside of pain, gastrointestinal side effects were the most common. Thirty-two percent of patients required more than one treatment cycle. CONCLUSION: Oral methotrexate can be used to treat ectopic pregnancy successfully, but there are few advantages to recommend its use over intramuscular methotrexate.
Gary H Lipscomb; Norman L Meyer; Darby E Flynn; Matt Peterson; Frank W Ling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  186     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-14     Completed Date:  2002-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1192-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, USA.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*,  adverse effects,  therapeutic use
Administration, Oral
Chorionic Gonadotropin / blood
Dose-Response Relationship, Drug
Drug Administration Schedule
Gastrointestinal Diseases / chemically induced
Methotrexate / administration & dosage*,  adverse effects,  therapeutic use
Pain / chemically induced
Pregnancy, Ectopic / blood,  drug therapy*,  ultrasonography
Treatment Outcome
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin; 59-05-2/Methotrexate

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