Document Detail

Oral medications for upper gastrointestinal endoscopy using a small diameter endoscope.
MedLine Citation:
PMID:  3410245     Owner:  NLM     Status:  MEDLINE    
We carried out a double-blinded, randomized prospective study to compare patient tolerance of small diameter endoscopes using limited potency oral premedication to complement topical anesthesia. Patients randomly received either oral placebo, diphenhydramine (100 mg), acetaminophen (1000 mg), or both drugs 30 to 60 min prior to endoscopy. All patients received topical Cetacaine and underwent upper endoscopy with the Olympus XP10 7.9-mm fiberscope. The combination of acetaminophen (1000 mg) and diphenhydramine (100 mg) significantly improved tolerance over topical anesthetic alone. Obvious sedation from the medications was infrequent. Gag response after a topical anesthesia was a significant predictor of patient tolerance. We conclude that small diameter endoscopes are well tolerated for diagnostic upper endoscopy. Oral premedications additionally improve tolerance slightly.
D C Pound; K W O'Connor; E D Brown; R Weddle; R McHenry; D Crabb; R Brunelle; G A Lehman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  34     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1988-10-06     Completed Date:  1988-10-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
Department of Medicine, Indiana University School of Medicine, Indianapolis.
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MeSH Terms
Acetaminophen / therapeutic use*
Administration, Oral
Anesthesia, Local
Diphenhydramine / therapeutic use*
Double-Blind Method
Fiber Optic Technology / instrumentation
Gastrointestinal Diseases / diagnosis*
Middle Aged
Prospective Studies
Random Allocation
Reg. No./Substance:
0/Placebos; 103-90-2/Acetaminophen; 58-73-1/Diphenhydramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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