| Oral matrix metalloproteinase inhibition and arterial remodeling after balloon dilation: an intravascular ultrasound study in the pig. | |
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MedLine Citation:
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PMID: 11208693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inhibition of matrix metalloproteinase (MMP) activity after balloon angioplasty by intraperitoneal injection of batimastat reduces late lumen loss by inhibition of constrictive remodeling. In the present study, we investigated whether the oral MMP inhibitor marimastat inhibits constrictive remodeling in favor of neutral or expansive remodeling. METHODS AND RESULTS: In 26 pigs, balloon dilation was performed in 101 peripheral arteries. Pigs were treated with marimastat or served as controls and were euthanized 42 days after intervention. Intravascular ultrasound was performed at all time points. Vessel area (VA) loss was assessed by calculating the change in VA at termination relative to after intervention. Arteries were divided in 3 categories: expansive remodeling (VA loss < -5%), neutral (-5% <or= VA loss <or= +5%), and constrictive remodeling (VA loss > +5%). In the marimastat group, a significant reduction (53%) of late lumen loss was observed that was fully explained by impaired constrictive remodeling. In the marimastat group, the prevalence of constrictive remodeling was reduced (38% versus 75% in the control group) in favor of not only neutral but also expansive remodeling (21% and 42% versus 4% and 21% in the control group, respectively, P:<0.01). In contrast to the control group, acute luminal gain in the marimastat group did not correlate with late VA loss. CONCLUSIONS: Irrespective of the acute luminal gain by balloon dilation, the oral MMP inhibitor marimastat inhibited constrictive arterial remodeling in favor of both neutral and expansive remodeling. |
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Authors:
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M J Sierevogel; G Pasterkamp; E Velema; P P de Jaegere; B J de Smet; J H Verheijen; D P de Kleijn; C Borst |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 103 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2004-07-08 Completed Date: 2004-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 302-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, University Medical Center, Utrecht, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Arteries / drug effects, enzymology, physiopathology*, ultrasonography* Balloon Dilatation / adverse effects* Enzyme Inhibitors / administration & dosage* Hydroxamic Acids / administration & dosage* Hyperplasia Matrix Metalloproteinases / antagonists & inhibitors* Swine Tunica Intima / ultrasonography Ultrasonography, Interventional |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Hydroxamic Acids; 154039-60-8/marimastat; EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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