Document Detail

Oral manifestations of gold allergy.
MedLine Citation:
PMID:  8288779     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sensitization to gold in a large group of patients suspected of clinical allergy to this metal has not been reported. OBJECTIVE: Two hundred patients with symptoms of persistent oral mucosal or cutaneous lesions that were possibly related to allergy to constituents of gold alloys or gold jewelry were patch tested to determine the frequency of sensitization. METHODS: Patch testing was performed with the European standard series and a series of dental materials including three different salts of gold. A persistent papular reaction to gold-(tri)chloride was considered a positive reaction. RESULTS: In 17 patients (8.5%, all women, mean age 50.2 years) persistent papular patch test reactions to both 0.5% and 1.0% gold(tri)chloride were observed. In five of seven patients with oral lichen planus (OLP) and in one of six patients with the burning mouth syndrome, gold in the dentures was replaced. Particularly in patients with OLP, a significant but variable improvement was observed. In all cases in which gold was replaced and improvement occurred, the patients were sensitized to 0.5% gold(tri)chloride. One patient with allergic contact stomatitis and one patient with allergic contact dermatitis healed completely after gold had been replaced. CONCLUSION: Sensitization to gold should be considered as a possible cause of allergic contact dermatitis and allergic contact stomatitis as well as a pathogenic or triggering factor in OLP.
R Laeijendecker; T van Joost
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  30     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-02-24     Completed Date:  1994-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-9     Citation Subset:  IM    
Department of Dermato-Venereology, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Burning Mouth Syndrome / etiology*
Dermatitis, Allergic Contact / diagnosis,  etiology*
Gold Alloys / adverse effects*
Lichen Planus, Oral / etiology*
Middle Aged
Patch Tests
Stomatitis / etiology*
Reg. No./Substance:
0/Gold Alloys

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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