| Oral magnesium supplementation improves vascular function in elderly diabetic patients. | |
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MedLine Citation:
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PMID: 20736142 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Magnesium (Mg) ions directly influence vascular tone and responsiveness and are cofactors for acetylcholine-induced endothelium-dependent relaxation. Alterations in extracellular Mg are able to modify the formation and release of nitric oxide (NO), altering arterial smooth muscle tone. Previous in vivo studies in humans have shown that parenteral or oral Mg supplementation increase endothelial-dependent vasodilation. The aim of the present study was to evaluate the effects of Mg oral supplementation on endothelial function in elderly diabetic and hypertensive subjects. Sixty elderly (≥ 65 years) diabetic patients were recruited (mean age: 71.1 ± 6.1 years; M/F: 35/25). Endothelial function, evaluated by non-invasive flow-mediated dilatation of the brachial artery, as well as anthropometric and laboratory data, including ionized Mg (Mg-ion), were measured in all patients before and after one-month. Thirty patients underwent oral Mg supplementation with 4.5 g/day of Mg pidolate (368 mg/day of Mg ion), while the rest were used as a control group. The usual management of diabetes and hypertension was not changed during the month of study participation for all the patients. In the group of patients that underwent Mg supplementation, Mg-ion concentration significantly increased from 0.42 ± 0.05 mmol/L to 0.49 ± 0.06 mmol/L; p < 0.05. Mg intervention resulted in a significant improvement of the post-ischemic endothelial-dependent flow-mediated dilation (from 3.3 ± 3.6% to 8.4 ± 3.9%; p < 0.05). No significant differences were found, either in ion-Mg or endothelial function, in the control group. In conclusion, the present study suggests that oral Mg improves endothelial function in diabetic elderly subjects. |
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Authors:
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Mario Barbagallo; Ligia J Dominguez; Antonio Galioto; Antonella Pineo; Mario Belvedere |
Publication Detail:
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Type: Journal Article Date: 2010-08-24 |
Journal Detail:
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Title: Magnesium research : official organ of the International Society for the Development of Research on Magnesium Volume: 23 ISSN: 0953-1424 ISO Abbreviation: Magnes Res Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900948 Medline TA: Magnes Res Country: England |
Other Details:
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Languages: eng Pagination: 131-7 Citation Subset: IM |
Affiliation:
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Geriatric Unit, Dept. of Internal Medicine and Emergent Pathologies, University of Palermo, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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