Document Detail

Oral magnesium load test in patients with migraine.
MedLine Citation:
PMID:  12005285     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether migraineurs may have a systemic deficiency of magnesium. BACKGROUND: Magnesium deficiency has been shown to play a potential role in the pathogenesis of migraine, but there are no data on total body magnesium status in migraineurs. METHODS: An oral magnesium load test was performed by giving 3000 mg of magnesium lactate during a 24-hour interictal period to 20 patients with migraine (15 women and 5 men; mean age, 37.9 years) and 20 healthy volunteers (16 women and 4 men; mean age, 39.6 years). Baseline and postload magnesium concentrations were determined from serum and 24-hour urine specimens. RESULTS: There was no significant difference between the groups in the baseline serum and urine magnesium concentrations, although the latter tended to be lower (P = .064) in the migraine group. The postload magnesium concentrations were significantly higher within both the migraine (P < .0001 and P < .0001) and the control (P = .0009 and P < .0001) groups compared to the baseline values. After loading, the 24-hour urinary magnesium excretions were significantly lower (P = .0007) in the patients with migraine than in the controls, but serum values did not differ. CONCLUSIONS: Magnesium retention occurs in patients with migraine after oral loading, suggesting a systemic magnesium deficiency.
Anita Trauninger; Zoltán Pfund; Tamás Koszegi; József Czopf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Headache     Volume:  42     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-05-13     Completed Date:  2002-06-28     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  IM    
Department of Neurology, Medical Faculty, University of Pécs, Hungary.
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MeSH Terms
Administration, Oral
Circadian Rhythm
Magnesium / blood,  diagnostic use*,  urine
Middle Aged
Migraine Disorders / metabolism*
Reference Values
Reg. No./Substance:

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