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Oral low-dose chemotherapy: Successful treatment of an alveolar rhabdomyosarcoma during pregnancy.
MedLine Citation:
PMID:  21241005     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We report for the first time the impact of neoadjuvant oral low-dose chemotherapy consisting of oral trofosfamide, idarubicin, and etoposide (O-TIE) in the case of alveolar rhabdomyosarcoma (RMS) in the lower jaw of an 18-year-old woman at 27 weeks of gestation, without fetal complications and a highly efficient anti-tumor response. Our study suggests the possible application of O-TIE treatment in a neoadjuvant setting during pregnancy and recommends a schedule that can be considered for the treatment of patients with high-risk sarcomas who cannot be treated with intensive chemotherapy for various reasons. Pediatr Blood Cancer © 2011 Wiley-Liss, Inc.
Authors:
Meinolf Siepermann; Ewa Koscielniak; Tobias Dantonello; Dirk Klee; Joachim Boos; Barbara Krefeld; Arndt Borkhardt; Thomas Hoehn; Alexzander Asea; Rüdiger Wessalowski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-16
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  -     ISSN:  1545-5017     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Clinic of Pediatric Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Duesseldorf, Germany.
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