Document Detail

Oral lichenoid lesions, mercury hypersensitivity and combined hypersensitivity to mercury and other metals: histologically-proven reproduction of the reaction by patch testing with metal salts.
MedLine Citation:
PMID:  8565487     Owner:  NLM     Status:  MEDLINE    
We report 11 patients seen between 1991 and 1994 with oral lichenoid lesions (OLL). In 10 cases, there was contact with dental amalgam fillings, and in patient no. 10 with both amalgam restorations and a gold crown. The last patient had, in addition to her OLL, lichen planus of the skin and genital mucosa. In 5 cases, combined sensitization to mercury and other metal salts, particularly gold sodium thiosulfate (GST) and palladium chloride (PDC), was observed. In 10 patients, the lesions considerably improved or totally cleared within 1 to 9 months of replacement of restoration materials. Histological examination of biopsies from the test sites of amalgam, mercuric chloride, GST and PDC, taken 10 or 17 days after application of patch tests, showed lichenoid changes in 7 patients with at least 1 of the allergens. As at least 2 patients had inflammatory lesions of the oral mucosa related to both amalgam and gold restorations, combined sensitization to inorganic and organic mercury derivatives, GST and, in 1 case, PDC, a "dental restoration metal intolerance syndrome" is proposed.
P Koch; F A Bahmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  33     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-03-06     Completed Date:  1996-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  323-8     Citation Subset:  IM    
Hautklinik der Universität des Saarlandes, Homburg/Saar, Germany.
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MeSH Terms
Allergens / adverse effects*
Dental Amalgam / adverse effects
Dental Restoration, Permanent / adverse effects
Dermatitis, Allergic Contact / etiology*,  pathology
Genital Diseases, Female / complications
Gold Alloys / adverse effects
Gold Sodium Thiosulfate / adverse effects
Lichen Planus / complications
Lichen Planus, Oral / complications
Lichenoid Eruptions / chemically induced*,  pathology
Mercuric Chloride / adverse effects
Mercury / adverse effects*
Metals / adverse effects*
Middle Aged
Mouth Diseases / chemically induced*,  pathology
Palladium / adverse effects
Patch Tests
Reg. No./Substance:
0/Allergens; 0/Gold Alloys; 0/Metals; 15283-45-1/Gold Sodium Thiosulfate; 7439-97-6/Mercury; 7440-05-3/Palladium; 7487-94-7/Mercuric Chloride; 7647-10-1/palladium chloride; 8049-85-2/Dental Amalgam

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