| Oral lesions indicative of plasminogen deficiency (hypoplasminogenemia). | |
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MedLine Citation:
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PMID: 11250632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gingival overgrowth with ulceration has recently been recorded in 4 reports: (1) our report of a British patient with ligneous conjunctivitis in whom the gingival lesions appeared to be related to tranexamic acid-an antifibrinolytic agent; (2) a report of 2 Turkish patients and an Italian patient with mainly gingival lesions; (3) our report of 5 Turkish patients with mainly gingival lesions; and (4) a report of 3 new Turkish cases, which also were associated with gingival lesions and alveolar bone loss. These patients all had gingival swellings, and a minority had conjunctival involvement similar to ligneous conjunctivitis, although the etiology was unclear in all. Nevertheless, fibrin exudation was fundamental because the hyaline or amyloidaceous material seen on the gingival biopsy stained for fibrin but failed to stain for amyloid. METHODS: We have examined 6 more patients who exhibited gingival swelling caused by amyloidaceous deposits that stained only for fibrin, and we assayed their plasminogen levels. RESULTS: The plasminogen functional activity assayed in these 6 additional patients, and in 2 of the 5 patients previously reported by us, was significantly reduced. CONCLUSIONS: Gingival overgrowth with ulceration appears to be a new complication caused by plasminogen deficiency; it also appears to be related to ligneous conjunctivitis in some cases. |
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Authors:
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C Scully; A Y Gokbuget; C Allen; J V Bagan; A Efeoglu; G Erseven; C Flaitz; S Cintan; T Hodgson; S R Porter; P Speight |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 91 ISSN: 1079-2104 ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-16 Completed Date: 2001-05-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 334-7 Citation Subset: D; IM |
Affiliation:
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Eastman Dental Institute for Oral Health Care Sciences, University College London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Protein Disorders / complications Child Conjunctivitis / etiology Female Gingival Diseases / etiology* Gingival Overgrowth / etiology Humans Male Oral Ulcer / etiology Plasminogen / deficiency* Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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9001-91-6/Plasminogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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