Document Detail


Oral lesions as an initial manifestation of dermatomyositis with occult malignancy.
MedLine Citation:
PMID:  16448919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dermatomyositis (DM) is an inflammatory disease of skeletal muscle with characteristic cutaneous features. Oral manifestations of DM have been very rarely described. This case describes a patient in whom the oral lesions were among the initial manifestations of DM. The lesions were very painful and the most distressing component of the disease in this patient. High dose systemic steroids were required to control the lesions. Investigations for an occult malignancy in this patient resulted in the identification of a non-Hodgkin's lymphoma in her right kidney. Commencement of chemotherapy rapidly resulted in complete resolution of her oral and skin lesions.
Authors:
Claire M Healy; Anne-Marie Tobin; Brian Kirby; Stephen R Flint
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  101     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-03-14     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  184-7     Citation Subset:  D; IM    
Affiliation:
Dublin Dental School and Hospital, Trinity College, Dublin, Ireland. claire.healy@dental.tcd.ie
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MeSH Terms
Descriptor/Qualifier:
Aged
Antineoplastic Agents / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Cyclophosphamide / administration & dosage
Dermatomyositis / complications*,  diagnosis,  drug therapy
Diagnosis, Differential
Doxorubicin / administration & dosage
Female
Gingivitis / drug therapy,  etiology*
Glucocorticoids / therapeutic use
Humans
Kidney Neoplasms / complications*,  drug therapy
Leukemia, B-Cell / complications*,  drug therapy
Mouth Mucosa / pathology
Oral Ulcer / drug therapy,  etiology*
Prednisolone / administration & dosage,  therapeutic use
Vincristine / administration & dosage
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Glucocorticoids; 0/VAP-cyclo protocol; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 57-22-7/Vincristine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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