Document Detail

Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers.
MedLine Citation:
PMID:  11854069     Owner:  NLM     Status:  MEDLINE    
Leiomyosarcoma of the oral cavity is a very rare tumor that is associated with aggressive clinical behavior and low survival. In this paper, we report two new cases of leiomyosarcoma affecting the mandibular gingiva and mandible of a 35-year-old male and the mandible of a 51-year-old female. Given the difficulty in the histopathologic discrimination between benign and malignant smooth muscle tumors and the absence of reliable histologic parameters for prognostication of leiomyosarcomas, we evaluated the diagnostic and prognostic value of various immunohistochemical and molecular markers. By means of immunohistochemistry and quantitative real-time PCR analysis, we detected protein expression of PCNA, bcl-2, CDK4, p53 and MDM2 in both our cases and MDM2 amplification in our second case. The literature, pertinent to oral leiomyosarcoma and to molecular analysis of smooth muscle tumors, is reviewed.
Nikolaos G Nikitakis; Marcio A Lopes; Jonathan S Bailey; Remy H Blanchaert; Robert A Ord; John J Sauk
Related Documents :
2001159 - The ectopic ovary. a case report and review of the literature.
639529 - Persistent left superior vena cava complicating hemodynamic monitoring catheterization.
19936119 - Antenatal sonographic diagnosis of pharyngeal teratoma: our experience of a rare case w...
20557709 - Benign teratoma of the tongue in a neonate: a case report and review of the literature.
11917229 - Leiomyosarcoma of the uterus with a florid intravascular component ("intravenous leiomy...
15086839 - Uterine leiomyoma with massive lymphoid infiltration: case report and review of the lit...
11816259 - Amphotericin b lipid complex for hansenula anomala pneumonia.
1202309 - Laryngopharyngeal injuries.
9231099 - Simultaneous occurrence of metastatic tonsillar squamous cell carcinoma and angioimmuno...
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Oral oncology     Volume:  38     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-20     Completed Date:  2002-04-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-8     Citation Subset:  IM    
Department of Oral and Maxillofacial Pathology, Dental School, University of Maryland, Baltimore 666 W. Baltimore Street, Room 4-C-02, Baltimore, MD 21201-1586, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Gingival Neoplasms / diagnosis*,  pathology
Leiomyosarcoma / diagnosis*,  pathology
Mandibular Neoplasms / diagnosis*,  pathology
Middle Aged
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity...
Next Document:  Clear cell odontogenic carcinoma.