Document Detail


Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers.
MedLine Citation:
PMID:  11854069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leiomyosarcoma of the oral cavity is a very rare tumor that is associated with aggressive clinical behavior and low survival. In this paper, we report two new cases of leiomyosarcoma affecting the mandibular gingiva and mandible of a 35-year-old male and the mandible of a 51-year-old female. Given the difficulty in the histopathologic discrimination between benign and malignant smooth muscle tumors and the absence of reliable histologic parameters for prognostication of leiomyosarcomas, we evaluated the diagnostic and prognostic value of various immunohistochemical and molecular markers. By means of immunohistochemistry and quantitative real-time PCR analysis, we detected protein expression of PCNA, bcl-2, CDK4, p53 and MDM2 in both our cases and MDM2 amplification in our second case. The literature, pertinent to oral leiomyosarcoma and to molecular analysis of smooth muscle tumors, is reviewed.
Authors:
Nikolaos G Nikitakis; Marcio A Lopes; Jonathan S Bailey; Remy H Blanchaert; Robert A Ord; John J Sauk
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Oral oncology     Volume:  38     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-20     Completed Date:  2002-04-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-8     Citation Subset:  IM    
Affiliation:
Department of Oral and Maxillofacial Pathology, Dental School, University of Maryland, Baltimore 666 W. Baltimore Street, Room 4-C-02, Baltimore, MD 21201-1586, USA. nin001@dental.umaryland.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Gingival Neoplasms / diagnosis*,  pathology
Humans
Leiomyosarcoma / diagnosis*,  pathology
Male
Mandibular Neoplasms / diagnosis*,  pathology
Middle Aged
Prognosis
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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