Document Detail


Oral labetalol versus oral clonidine in the emergency treatment of severe hypertension.
MedLine Citation:
PMID:  1728876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to compare the clinical efficacy and safety of oral clonidine and oral labetalol in the treatment of severe hypertension in an emergency department setting. Thirty-six patients with severely elevated blood pressure (mean baseline blood pressure 199/132 mm Hg) without acute end-organ dysfunction were treated with either oral labetalol or oral clonidine in a randomized double-blind prospective study. Labetalol was administered as an initial dose of 200 mg, followed by hourly 200 mg doses up to 1,200 mg. Clonidine was administered as an initial dose of 0.2 mg, followed by hourly 0.1 mg doses up to 0.7 mg. Labetalol reduced diastolic blood pressure in 94% of the patients within 6 hours, with a mean reduction in blood pressure of 54/37 mm Hg. Clonidine reduced diastolic blood pressure in 83% of the patients within 6 hours, with a mean reduction in blood pressure of 57/32 mm Hg. The authors conclude that oral labetalol was comparable to clonidine in efficacy, had a similar incidence of side effects, and offered the clinician a useful alternative for the treatment of severe hypertension in an emergency department setting. Further studies are indicated to determine appropriate dosing regimens for oral labetalol in the acute treatment of severe hypertension.
Authors:
S H Atkin; M A Jaker; P Beaty; M A Quadrel; C Cuffie; M L Soto-Greene
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  303     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-06     Completed Date:  1992-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, University Hospital, Newark 07103-2425.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Blood Pressure / drug effects
Clonidine / administration & dosage,  therapeutic use*
Diastole / drug effects
Emergencies*
Female
Heart Rate / drug effects
Humans
Hypertension / drug therapy*,  physiopathology
Labetalol / administration & dosage,  therapeutic use*
Male
Middle Aged
Systole / drug effects
Time Factors
Chemical
Reg. No./Substance:
36894-69-6/Labetalol; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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