Document Detail

Oral ketamine controlled refractory nonconvulsive status epilepticus in an elderly patient.
MedLine Citation:
PMID:  21724423     Owner:  NLM     Status:  MEDLINE    
Nonconvulsive status epilepticus (NCSE) is a heterogeneous disorder with different seizure types and diverse etiologies, and is mainly characterized by altered consciousness. The recognition of NCSE is more challenging than generalized convulsive SE, and diagnosis and treatment are often delayed. Therefore, some cases can evolve into refractory SE and become pharmacoresistant even with GABAergic anesthetics. Herein we report the successful clinical experience of pharmacoresistant complex partial SE treated with ketamine. An elderly woman was profoundly stuporous and had relentless clonic movements of the right hand and forearm. Electroencephalography revealed repetitive periodic lateralized epileptiform discharges (PLEDs). There was a poor clinical response to standard anticonvulsants and GABAergic anesthetics. Both the clinical and electroencephalographic SE were controlled after intravenous ketamine therapy. Rebound refractory NCSE occurred about six days after discontinuing the intravenous ketamine, which was successfully terminated by oral ketamine treatment. There were no adverse effects observed.
Poh-Shiow Yeh; Hsiu-Nien Shen; Tai-Yuan Chen
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-07-02
Journal Detail:
Title:  Seizure     Volume:  20     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2012-07-30     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  723-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Administration, Oral
Ketamine / administration & dosage*
Status Epilepticus / diagnosis*,  drug therapy*,  physiopathology
Reg. No./Substance:

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