| Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne. | |
| | |
MedLine Citation:
|
PMID: 18401903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Due to the late introduction of oral isotretinoin, there is only a single report of the use of this drug from India. AIMS: To evaluate the efficacy, acceptability and side effects of oral isotretinoin in Indian conditions and to compare the efficacy of oral isotretinoin monotherapy with that of a combination of oral isotretinoin and topical anti-acne agents. METHODS: Sixty clinically diagnosed patients of nodulocystic acne were divided into two groups of 30 each. Patients in group A were administered oral isotretinoin 20 mg twice a day along with topical clindamycin (1%) and adapalene (0.1%) for 24 weeks. Patients in group B were given only oral isotretinoin. An objective clinical scoring was repeated every four weeks and patients were followed up for six months on completion of treatment. RESULTS: Out of the 60 patients, 50 completed the treatment and 35 completed the follow-up at six months. The mean pretreatment score in group A came down from 12.8 to 1.24 and in group B from 12.4 to 1.48, thus showing a 90.55% and 88% reduction in pretreatment scores respectively. There was no statistical difference in the results obtained from the two groups. Side effects were common but minor in nature. CONCLUSION: Isotretinoin produces gratifying results in patients of nodulocystic acne in Indian conditions. Addition of topical antiacne agents does not alter the final outcome. This addition is well tolerated but requires careful monitoring. |
| | |
Authors:
|
Rajeev Dhir; Neetu P Gehi; Reetu Agarwal; Yuvraj E More |
Related Documents
:
|
2645323 - Treatment of bullous pemphigoid with topical clobetasol propionate. 17492843 - Efficacy and safety of etanercept in psoriasis/psoriatic arthritis: an updated review. 19189173 - Lateral subfascial endoscopic perforating vein surgery as treatment for lateral perfora... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Indian journal of dermatology, venereology and leprology Volume: 74 ISSN: 0973-3922 ISO Abbreviation: Indian J Dermatol Venereol Leprol Publication Date: 2008 Mar-Apr |
Date Detail:
|
Created Date: 2008-04-10 Completed Date: 2008-07-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7701852 Medline TA: Indian J Dermatol Venereol Leprol Country: India |
Other Details:
|
Languages: eng Pagination: 187 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, INHS Asvini, Mumbai, Maharashtra, India. dhir_rajeev@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acne Vulgaris
/
drug therapy*,
pathology Administration, Oral Administration, Topical Adolescent Adult Child Dermatologic Agents / administration & dosage* Drug Therapy, Combination Female Follow-Up Studies Humans Isotretinoin / administration & dosage* Male |
| Chemical | |
Reg. No./Substance:
|
0/Dermatologic Agents; 4759-48-2/Isotretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Consumer-directed health plans: mixed employer signals, complex market dynamics.
Next Document: Wound closure and gradual involution of an infantile hemangioma using a noncontact, low-frequency ul...