Document Detail

Oral involvement in mycosis fungoides: report of two cases and a literature review.
MedLine Citation:
PMID:  11028868     Owner:  NLM     Status:  MEDLINE    
Oral involvement is uncommon in cutaneous T-cell lymphomas and usually associated with poor prognosis. The clinicopathological and immunohistochemical findings of 2 new cases are described along with a literature review. The first patient had a 10-year history of mycosis fungoides when she developed lesions in the oral tissues. She died 6 months later despite treatment. The immunophenotype was CD3+, CD4+, CD8-, CD30-. The second patient had a mycosis fungoides for 5 years when she developed lesions in the uvula and oropharynx. She was treated with polychemotherapy and she is alive 5 years after oral involvement. The immunophenotype was CD3+, CD4-, CD8+, CD30-. There are conflicting reports about the prognosis in the CD8+ phenotype. The present cases and the literature review seem to indicate that in oral involvement the CD8- phenotype is not associated with a worse prognosis than the CD4+ subtype. However, it is necessary to study new cases to confirm this statement.
E G de la Fuente; J L Rodriguez-Peralto; P L Ortiz; N Barrientos; F Vanaclocha; L Iglesias
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  80     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2001-02-05     Completed Date:  2001-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  299-301     Citation Subset:  IM    
Department of Dermatology, 12 de Octubre University Hospital, Madrid, Spain.
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MeSH Terms
Antigens, CD4 / analysis
Antigens, CD8 / analysis
Middle Aged
Mouth Neoplasms / pathology,  secondary*
Mycosis Fungoides / pathology*
Oropharyngeal Neoplasms / secondary
Skin Neoplasms / pathology*
Tongue Neoplasms / secondary
Reg. No./Substance:
0/Antigens, CD4; 0/Antigens, CD8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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