Document Detail

Oral intake and serum levels of ascorbic acid in continuous ambulatory peritoneal dialysis patients.
MedLine Citation:
PMID:  11510279     Owner:  NLM     Status:  MEDLINE    
Oral intake of ascorbic acid is essential for optimum health in human beings. Continuous ambulatory peritoneal dialysis (CAPD) patients have an increased need for ascorbic acid, because of increased loss through dialysate, reduced intake owing to nausea and loss of appetite, and increased oxidative stress. However, optimum intake is still controversial. We studied 50 clinically stable patients to determine the relationship between oral ascorbic acid intake and serum ascorbic acid (SAA) level. Total oral intake ranged from 28 mg daily to 412 mg daily. Only one patient had an oral intake of ascorbic acid below 60 mg per day. The SAA levels ranged from 1 mg/L to 36.17 mg/L. Although a strong correlation existed between intake and SAA (p < 0.001, R2 = 0.47), the variation in SAA at any given intake level was wide. Of the studied patients, 62% had an SAA < 8.7 mg/L, 40% had an SAA < 5.1 mg/L (below the level in a healthy population), and 12% had a level below 2 mg/L (scorbutic). None of the patients demonstrated clinical manifestations of scurvy. Our results show that, in CAPD patients, ascorbic acid deficiency can be reliably detected only with SAA measurements, and oral intake may influence SAA level. To maintain ascorbic acid in the normal range for healthy adults, daily oral intake needs to be increased above the U.S. recommended dietary allowance to 80-140 mg.
S L Lim; E J Lee; C C Myint; K T Ong; M E Tay; N Yusuf; C N Ong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  17     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-20     Completed Date:  2002-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  215-8     Citation Subset:  IM    
Division of Nephrology, Department of Medicine, National University Hospital, National University of Singapore, Singapore.
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MeSH Terms
Aged, 80 and over
Ascorbic Acid / administration & dosage*,  blood*
Ascorbic Acid Deficiency / diagnosis
Dietary Supplements
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
Reg. No./Substance:
50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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