| Oral insulinlike growth factor-I stimulates intestinal enzyme maturation in newborn rats. | |
| | |
MedLine Citation:
|
PMID: 9200669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Insulinlike growth factor-I (IGF-I) has been found in the milk of various species. To investigate if milk-borne IGF-I has any effect on postnatal gut development in neonatal animals, newborn rat pups were given orally 1 microg recombinant human IGF-I daily for 3 days. For comparison, a separate group of newborn pups was given 150 microg hydrocortisone, the hormone known to stimulate intestinal maturation in neonatal rats. Oral IGF-I treatment had no significant effect on the animal body weight nor on the weight of the stomach, small and large intestines, and pancreas. Oral administration of hydrocortisone significantly reduced body weight gain, but it had no apparent effect on internal organ weights. Both IGF-I and hydrocortisone treatments, however, significantly increased lactase, maltase and sucrase activities and hydrocortisone significantly increased aminopeptidase activity at the proximal small intestine when compared with the control. The finding supports the hypothesis that milk-borne IGF-I may play a role in regulating postnatal gut development in the suckling young. |
| | |
Authors:
|
L Ma; R J Xu |
Related Documents
:
|
15539269 - Effects of dietary polyamines and clofibrate on metabolism of polyamines in the rat. 2814039 - Effects of ceruletide on post-operative intestinal atony: a manometric study. 879129 - Influence of carbon chain length of dietary fat on intestinal alkaline phosphatase in c... 7570589 - Activation of ornithine decarboxylase in epithelial cells of rat intestine. 2544629 - Active proton secretion and potassium absorption in the rabbit outer medullary collecti... 1972969 - Dietary modulation of small intestinal glutamine transport in intestinal brush border m... 6887299 - Congenital deformities in swine induced by wild tree tobacco, nicotiana glauca. 22223239 - Ezetimibe and regression of carotid atherosclerosis: importance of measuring plaque bur... 941789 - Effect of a cholesterol-rich diet on cholesterol content and phagocytic activity of rat... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Life sciences Volume: 61 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1997 |
Date Detail:
|
Created Date: 1997-07-21 Completed Date: 1997-07-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 51-8 Citation Subset: IM |
Affiliation:
|
Department of Zoology, The University of Hong Kong. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn / physiology Insulin-Like Growth Factor I / administration & dosage, pharmacology* Intestines / drug effects* Rats Rats, Wistar Sucrase / drug effects* alpha-Glucosidases / drug effects* beta-Galactosidase / drug effects* |
| Chemical | |
Reg. No./Substance:
|
67763-96-6/Insulin-Like Growth Factor I; EC 3.2.1.20/alpha-Glucosidases; EC 3.2.1.23/beta-Galactosidase; EC 3.2.1.48/Sucrase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of nitric oxide facilitates LH release from rat pituitaries.
Next Document: Beta-3 adrenoceptor (beta-3AR) expression in leptin treated OB/OB mice.