Document Detail

Oral immunotherapy for food allergy.
MedLine Citation:
PMID:  20852423     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: Food allergy is a difficult clinical problem for which no disease-modifying therapy currently exists.
RECENT FINDINGS: The daily administration of graded allergen doses through oral immunotherapy (OIT) is one promising experimental approach to the development of a clinically available treatment. Although the concept of oral immunologic tolerance is not new, OIT as a treatment for food allergy is innovative. Over the last few years, several groups of investigators have begun to demonstrate safety and varying degrees of efficacy and immune modulation in uncontrolled pilot studies of OIT. Rigorously designed trials are currently underway and important unanswered questions remain.
SUMMARY: OIT for food allergy holds promise for patients with food allergy but additional research is necessary before this approach is ready for clinical use.
Brian P Vickery; Wesley Burks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  22     ISSN:  1531-698X     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-05-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  765-70     Citation Subset:  IM    
Division of Pediatric Allergy and Immunology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
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