Document Detail

Oral immunotherapy for food allergy.
MedLine Citation:
PMID:  19063824     Owner:  NLM     Status:  MEDLINE    
Current management of food allergy involves strict avoidance, education on recognizing and managing allergic reactions, and carrying an adrenaline autoinjector. This approach is burdensome and associated with reduced quality of life. Patients with food allergy would benefit greatly from a treatment that could achieve desensitization or long-term tolerance. Recent studies have shown that oral immunotherapy (OIT) can induce desensitization and modulate allergen-specific immune responses; however, it remains uncertain whether OIT can induce long-term tolerance. Nevertheless, successful desensitization provides a major advance in management by reducing the risk of reaction to low amounts of allergen. Allergic reactions during OIT are common, although severe reactions are less common. Therefore, OIT should be performed in specialist centers under close medical supervision and would ideally be conducted as part of ongoing research studies. OIT holds promise as a novel approach to managing food allergy.
Mimi L K Tang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current allergy and asthma reports     Volume:  9     ISSN:  1534-6315     ISO Abbreviation:  Curr Allergy Asthma Rep     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-09     Completed Date:  2009-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101096440     Medline TA:  Curr Allergy Asthma Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Victoria, Melbourne, Australia.
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MeSH Terms
Administration, Cutaneous
Administration, Oral
Administration, Sublingual
Allergens / administration & dosage*
Cytokines / immunology
Desensitization, Immunologic / methods*
Food Hypersensitivity / therapy*
T-Lymphocytes, Regulatory / immunology
Reg. No./Substance:
0/Allergens; 0/Cytokines

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