Document Detail


Oral immunoadjuvant activity of Lactobacillus casei subsp. casei in dextran-fed layer chickens.
MedLine Citation:
PMID:  16469163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recently reported that synbiotic Lactobacillus casei subsp. casei together with specific substrate dextran elicited an enhancement in humoral immune response against bovine serum albumin (BSA) as a model antigen in BALB/c mice. The present study was designed to evaluate the oral immunoadjuvant effects of the synbiotic in layer chickens. Using a PCR assay, L. casei subsp. casei was detected specifically in the intestinal chyme of chickens (10 d of age, Julia strain) fed ad libitum on a diet supplemented with 75 mg dextran/kg (dextran-supplemented diet, DSD) and administered orally with 10(7) colony-forming units (CFU) L. casei subsp. casei in 0.1 ml PBS with the aid of an intubation needle at 1, 2 and 3 d of age. Furthermore, oral administration of 10(7) CFU L. casei subsp. casei at 1-3 d of age significantly enhanced the production of anti-BSA antibody in DSD-fed chickens (60 d of age) administered orally with 1 mg BSA at 32 and 33 d of age and subcutaneously with 5 microg BSA at 33 d of age. In addition, among bacterial numbers tested, 10(6) CFU L. casei subsp. casei together with dextran induced an effective increase in humoral immune response to mixed inactivated vaccines against Newcastle disease and avian infectious bronchitis, and the treatment may be advantageous in protecting against these infectious diseases in chickens in actual application. These results suggest that dietary supplementation of L. casei subsp. casei with dextran leads to immunomodulation of humoral immune responses.
Authors:
Tomohiko Ogawa; Yasuyuki Asai; Hiromi Sakamoto; Kenji Yasuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  95     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-10     Completed Date:  2006-03-14     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  430-4     Citation Subset:  IM    
Affiliation:
Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan. tomo527@dent.asahi-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic
Administration, Cutaneous
Administration, Oral
Animal Feed
Animals
Chickens / immunology*
Coronavirus Infections / immunology
Dextrans / administration & dosage*
Immunoglobulin G / biosynthesis
Infectious bronchitis virus / immunology
Intestines / microbiology
Lactobacillus casei / immunology*,  isolation & purification
Male
Newcastle Disease / immunology
Newcastle disease virus / immunology
Probiotics / administration & dosage*
Vaccines, Inactivated / immunology
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Immunoglobulin G; 0/Vaccines, Inactivated; 9004-54-0/Dextrans

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