Document Detail

Oral immunization to milk protein in human infants in the presence of passive antibody.
MedLine Citation:
PMID:  6622107     Owner:  NLM     Status:  MEDLINE    
The possible influence of maternal antibody on the immune response to bovine serum albumin (BSA), a normal cow's milk protein, was investigated in fullterm human neonates. Antibody production to BSA of 12 infants with passively acquired anti-BSA (Group I) was compared to the immune response of nine infants without passive anti-BSA at birth (Group II) during the first 6 months of life. All infants were raised on commercial cow's milk formulas containing BSA in concentrations from 0.4-4.0 mg/dl. From 4 wk of age concentrations of circulating anti-BSA as measured by radioimmunoassay and enzyme-linked-immunosorbent-assay (ELISA) were higher in Group II, but differences were not statistically significant. There was no differences in the immune response between infants ingesting formulas with high BSA content compared to infants ingesting low concentrations of antigenic BSA. The main isotype associated with anti-BSA formation was IgG. IgA in measurable amounts appeared later and accounted for approximately 10% of circulating antibody in both groups at 6 months of age. Ony small amounts of IgM- and IgE-anti-BSA were detected.
W Müller; A Lippmann; C H Rieger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  17     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  724-8     Citation Subset:  IM    
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MeSH Terms
Antibodies / analysis
Antibody Formation*
Immunity, Maternally-Acquired*
Immunoglobulin A / analysis
Immunoglobulin E / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Infant Food / analysis
Infant, Newborn
Milk Proteins / immunology*
Serum Albumin, Bovine / analysis,  immunology*
Reg. No./Substance:
0/Antibodies; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Milk Proteins; 0/Serum Albumin, Bovine; 37341-29-0/Immunoglobulin E

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