Document Detail


Oral hypoglycemic sulfonylurea glimepiride preserves the myoprotective effects of ischemic preconditioning.
MedLine Citation:
PMID:  12121705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To investigate whether the sulfonylurea glimepiride affects the myoprotective effects of ischemic preconditioning (IPC), isolated rabbit hearts were perfused with Krebs-Henseleit solution. METHODS: Eight hearts underwent IPC consisting of two cycles of 5 min global ischemia and reperfusion. Six hearts received a 5-min infusion of 10 microM glimepiride, six hearts received a 5-min infusion of 50 microM glimepiride, and seven hearts received a 5-min infusion of 10 microM glibenclamide before IPC. Seven hearts received a 5-min infusion of the selective mitochondrial K(ATP) channel opener diazoxide (50 microM). Other hearts received a 5-min infusion of 10 microM glimepiride (n = 6), 50 microM glimepiride (n = 6), or 10 microM glibenclamide (n = 7) before diazoxide. Seven hearts served as a control. All groups then were subjected to 1 h of regional ischemia, followed by 1 h of reperfusion. LV pressures, monophasic action potential duration (APD(50)), and infarct size were measured. RESULTS: Both IPC and diazoxide significantly prolonged APD(50) and preserved diastolic function at 60 min of reperfusion compared to control. In addition, both groups reduced infarct size compared to control. Glibenclamide, but not glimepiride reversed these effects. CONCLUSION: Glimepiride offers less cardiovascular effects than glibenclamide, possibly due to its lower affinity for the mitochondrial K(ATP) channels.
Authors:
Hitoshi Horimoto; Yasunari Nakai; Shigetoshi Mieno; Yukiya Nomura; Kenichi Nakahara; Shinjiro Sasaki
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  105     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-8     Citation Subset:  IM    
Affiliation:
Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, Takatsuki, Osaka, Japan. tho043@poh.osaka-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Coronary Circulation / drug effects
Heart / drug effects*,  physiopathology*
Hypoglycemic Agents / pharmacology*
Ischemic Preconditioning, Myocardial*
Male
Myocardial Infarction / pathology
Pressure
Rabbits
Reaction Time
Sulfonylurea Compounds / pharmacology*
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Sulfonylurea Compounds; 93479-97-1/glimepiride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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