Document Detail

Oral hypoglycaemic agents in 118 diabetic pregnancies.
MedLine Citation:
PMID:  10972579     Owner:  NLM     Status:  MEDLINE    
AIMS: To assess maternal and neonatal complications in pregnancies of diabetic women treated with oral hypoglycaemic agents during pregnancy. METHODS: A cohort study including all consecutively registered, orally treated pregnant diabetic patients set in a diabetic obstetrical service at a university hospital: 50 women treated with metformin, 68 women treated with sulphonylurea during pregnancy and a reference group of 42 diabetic women treated with insulin during pregnancy. RESULTS: The prevalence of pre-eclampsia was significantly increased in the group of women treated with metformin compared to women treated with sulphonylurea or insulin (32 vs. 7 vs. 10%, P < 0.001). No difference in neonatal morbidity was observed between the orally treated and insulin-treated group; no cases of severe hypoglycaemia or jaundice were seen in the orally treated groups. However, in the group of women treated with metformin in the third trimester, the perinatal mortality was significantly increased compared to women not treated with metformin (11.6 vs. 1.3%, P < 0.02). CONCLUSION: Treatment with metformin during pregnancy was associated with increased prevalence of pre-eclampsia and a high perinatal mortality.
E Hellmuth; P Damm; L Mølsted-Pedersen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  17     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-12     Completed Date:  2000-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  507-11     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, The Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Denmark.
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MeSH Terms
Abruptio Placentae / epidemiology
Birth Weight
Cesarean Section / statistics & numerical data
Cohort Studies
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes, Gestational / drug therapy*
Fetal Death / epidemiology
Hypoglycemic Agents / therapeutic use*
Infant, Newborn
Infant, Newborn, Diseases / classification,  epidemiology
Insulin / therapeutic use*
Metformin / therapeutic use*
Pre-Eclampsia / epidemiology
Pregnancy Outcome
Pregnancy in Diabetics / drug therapy*
Tolbutamide / therapeutic use*
Reg. No./Substance:
0/Hypoglycemic Agents; 11061-68-0/Insulin; 64-77-7/Tolbutamide; 657-24-9/Metformin
Comment In:
Diabet Med. 2001 Jul;18(7):604-5   [PMID:  11553194 ]

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