Document Detail


Oral hypoglycaemic agents: the first thirty years.
MedLine Citation:
PMID:  1573584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of 1,333 patients with non-insulin dependent diabetes (NIDDM) treated with oral hypoglycaemic agents (OHAs) between 1956 and 1988 is described. In addition there were 137 patients with insulin dependent diabetes (IDDM). When last on OHAs 51% of the patients with NIDDM were free from symptoms and satisfactorily controlled; 262 patients are known to have died, 223 have had to be changed to insulin and in 41 patients it has been possible to stop OHAs as no longer being needed, usually owing to better dietary compliance. Over the 32 years, 606 patients have been lost to follow-up; this represents 6.3% per year. The rate of development of secondary failure between the first and 20th year of treatment has been about 5% per year. Patients with NIDDM treated with OHAs have been more likely to develop clinically significant neuropathy and peripheral vascular disease; they also had a higher incidence of coronary artery disease than those treated with insulin. OHAs were used in the treatment of 110 patients with IDDM in the early stages of the disease; 44% achieved satisfactory blood glucose control for at least 12 months and a few patients for as long as 10 years. Of those with IDDM treated with OHAs, 44 were under 30 years of age; 55% had well controlled blood glucose levels for more than 12 months (median 2.8 years). Side effects have not been a real problem; 27 patients reported episodes of mild hypoglycaemia, skin rashes occurred in 1% of patients on sulphonylureas, and gastrointestinal symptoms in about 4% of those on biguanide.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J D Nabarro
Related Documents :
14743894 - Acute idiopathic pancreatitis: does it really exist or is it a myth?
4071344 - Disproportionate steatorrhoea in alcohol-induced calcific pancreatitis.
527874 - Trypsin and lactoferrin levels in pure pancreatic juice in patients with pancreatic dis...
8607504 - Maldigestion after total gastrectomy is associated with pancreatic insufficiency.
8674324 - An increase in serum c18 unsaturated free fatty acids as a predictor of the development...
24075374 - Treatment of infertile women with unilateral tubal occlusion by intrauterine inseminati...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Royal College of Physicians of London     Volume:  26     ISSN:  0035-8819     ISO Abbreviation:  J R Coll Physicians Lond     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-02     Completed Date:  1992-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503108     Medline TA:  J R Coll Physicians Lond     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Affiliation:
Middlesex Hospital, London.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Blood Glucose / analysis
Coronary Disease / epidemiology,  etiology
Diabetes Mellitus, Type 1 / blood,  complications,  drug therapy*
Diabetes Mellitus, Type 2 / blood,  complications,  drug therapy*
Diabetic Neuropathies / epidemiology,  etiology
Female
Follow-Up Studies
Hospitals, Urban
Humans
Hypoglycemic Agents / administration & dosage,  adverse effects,  therapeutic use*
Incidence
London / epidemiology
Male
Middle Aged
Obesity / epidemiology,  etiology
Patient Dropouts
Peripheral Vascular Diseases / epidemiology,  etiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Venous thromboembolism and travel: is there an association?
Next Document:  The decline in geriatric long stay beds: who remains?