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Oral human papillomavirus infection in HIV-negative and HIV-infected men who have sex with men: the HIV & HPV in MSM (H2M) study.
MedLine Citation:
PMID:  23612006     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected men who have sex with men (MSM). DESIGN:: Analysis of baseline data from a prospective cohort study. METHODS:: MSM aged ≥18 years were recruited from 3 study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay (SPF10-PCR DEIA/LiPA25 system). RESULTS:: In 2010-11, 794 MSM were included, of whom 767 participants had sufficient data for analysis. Median age was 40.1 years (IQR 34.8-47.5) and 314 men were HIV-infected (40.9%). Any of 25 typable HPV types was present in 24.4% of all oral samples. Oncogenic HPV types were detected in 24.8% and 8.8% of oral samples from HIV-infected and HIV-negative MSM, respectively (P < 0.001). Of these high-risk types, HPV-16 was the most common (overall 3.4%). Oral infection with high-risk HPV was associated with HIV infection in multivariable analysis (P < 0.001). Increasing age was significantly associated with oral HPV infection in HIV-negative, but not in HIV-infected MSM. CONCLUSIONS:: Oral HPV infection is very common among MSM. HIV infection was independently associated with high-risk oral HPV infection, suggesting an important role of HIV in oral HPV infection.
Authors:
Sofie H Mooij; Hein J Boot; Arjen Gcl Speksnijder; Ineke G Stolte; Chris J L M Meijer; Peter J F Snijders; Dominique W M Verhagen; Audrey J King; Henry J C D E Vries; Wim G V Quint; Marianne A B Van Der Sande; Maarten F Schim Van Der Loeff
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-22
Journal Detail:
Title:  AIDS (London, England)     Volume:  -     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aCluster Infectious Diseases, Public Health Service Amsterdam, P.O. Box 2200, 1000 CE, Amsterdam, the Netherlands bCentre for Infectious Diseases Control, National Institute for Public Health and the Environment (Rijksinstituut voor Volksgezondheid en Milieu, RIVM), P.O. Box 1, 3720 BA, Bilthoven, the Netherlands cDepartment of Pathology, Vrije Universiteit-University Medical Center (VUmc), P.O Box 7057, 1007 MB Amsterdam, the Netherlands dDepartment of Internal Medicine, Jan van Goyen Medical Center, Jan van Goyenkade 1, 1075 HN Amsterdam, the Netherlands eDepartment of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands fDepartment of Dermatology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands gDDL Diagnostic Laboratory B.V., Visseringlaan 25, 2288 ER Rijswijk, the Netherlands hJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
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