| Oral glycerol for the treatment of traumatic intracranial hypertension. | |
| | |
MedLine Citation:
|
PMID: 7057229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperosmolar agents are a primary therapeutic modality employed in the treatment of traumatic intracranial hypertension. Profound hyperosmolarity accompanied by systemic dehydration is a potentially serious problem when these drugs are used repeatedly for control of intracranial pressure. Because glycerol, a water-soluble alcohol, is metabolized in the liver, its dehydrating capacity may be reduced in comparison to other agents. A series of 15 patients were treated with oral glycerol (0.5 to 1.0 gm/kg) with only minor changes in serum electrolytes, glucose, and urea nitrogen. Serum osmolarity rose from a baseline of 305 mOsm/liter to 355 mOsm/liter after 10 days of therapy. Glycerol was found to be effective and safe when employed in this protocol and proved to be a valuable adjunct to the standard methods available for control of intracranial hypertension. |
| | |
Authors:
|
S L Wald; R L McLaurin |
Related Documents
:
|
14971569 - Rotatory nystagmus synchronous with heartbeat: a treatable form of nystagmus. 1006739 - Dynamic response of the intracranial system in the conscious dog to papaverine hydrochl... 3008519 - Near infrared spectrophotometry: potential role during increased intracranial pressure. 21380549 - Structural abnormalities of small resistance arteries in essential hypertension. 8345369 - Clinical experience with a fiberoptic intracranial pressure monitor. 18261779 - Slope of the intracranial pressure waveform after traumatic brain injury. 7114299 - Fetal and maternal arterial pressures and heart rates: histograms, correlations, and rh... 3045459 - Catecholamine-induced cardiovascular disease in the spontaneously hypertensive and athe... 22906879 - Synthesis of novel ru(2)c under high pressure-high temperature conditions. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of neurosurgery Volume: 56 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 1982 Mar |
Date Detail:
|
Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 323-31 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adolescent Adult Child Child, Preschool Craniocerebral Trauma / blood, complications Electrolytes / blood Female Glycerol / administration & dosage, adverse effects, blood, therapeutic use* Humans Intracranial Pressure / drug effects* Male Pseudotumor Cerebri / drug therapy*, etiology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Electrolytes; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical and pathological study of meningiomas of the first two decades of life.
Next Document: Effects of experimental fluid-percussion injury of the brain on cerebrovascular reactivity of hypoxi...