Document Detail

Oral glucose ingestion increases endurance capacity in normal and diabetic (type I) humans.
MedLine Citation:
PMID:  9262459     Owner:  NLM     Status:  MEDLINE    
The effects of an oral glucose administration (1 g/kg) 30 min before exercise on endurance capacity and metabolic responses were studied in 21 type I diabetic patients [insulin-dependent diabetes mellitus (IDDM)] and 23 normal controls (Con). Cycle ergometer exercise (55-60% of maximal O2 uptake) was performed until exhaustion. Glucose administration significantly increased endurance capacity in Con (112 +/- 7 vs. 125 +/- 6 min, P < 0.05) but only in IDDM patients whose blood glucose decreased during exercise (70.8 +/- 8.2 vs. 82.8 +/- 9.4 min, P < 0.05). Hyperglycemia was normalized at 15 min of exercise in Con (7.4 +/- 0.2 vs. 4.8 +/- 0.2 mM) but not in IDDM patients (12.4 +/- 0.7 vs. 15.6 +/- 0.9 mM). In Con, insulin and C-peptide levels were normalized during exercise. Glucose administration decreased growth hormone levels in both groups. In conclusion, oral glucose ingestion 30 min before exercise increases endurance capacity in Con and in some IDDM patients. In IDDM patients, in contrast with Con, exercise to exhaustion attenuates hyperglycemia but does not bring blood glucose levels to preglucose levels.
P R Ramires; C L Forjaz; C M Strunz; M E Silva; J Diament; W Nicolau; B Liberman; C E Negrão
Related Documents :
14678869 - Novel actions of thiazolidinediones on vascular function and exercise capacity.
9140899 - Training enhanced hepatic gluconeogenesis: the importance for glucose homeostasis durin...
3325489 - Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery...
2312459 - Skeletal muscle plasma membrane glucose transport and glucose transporters after exercise.
10099719 - Lack of effects of an acute hepatic vagotomy on insulin and catecholamine responses in ...
385299 - Bombesin stimulates the release of insulin and glucagon, but not pancreatic somatostati...
14698989 - Spatial distribution of hypoxic pulmonary vasoconstriction in the supine pig.
10710129 - The positive inotropic effects of milrinone but not of digoxin are attenuated at short ...
8100219 - Doppler sonographic examination of the internal mammary artery graft: influence of exer...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  83     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-15     Completed Date:  1997-09-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  608-14     Citation Subset:  IM    
Physical Education School, Endocrinology Unit, and Heart Institute, University of São Paulo 05508-900, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Diabetes Mellitus, Type 1 / blood,  physiopathology*
Glucose / pharmacology*
Hormones / blood
Physical Endurance / drug effects*
Pulmonary Gas Exchange / drug effects
Reference Values
Reg. No./Substance:
0/Hormones; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of effects of sustained isocapnic hypoxia on ventilation in men and women.
Next Document:  Role for anions in pulmonary endothelial permeability.