Document Detail


Oral glucose ingestion increases endurance capacity in normal and diabetic (type I) humans.
MedLine Citation:
PMID:  9262459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of an oral glucose administration (1 g/kg) 30 min before exercise on endurance capacity and metabolic responses were studied in 21 type I diabetic patients [insulin-dependent diabetes mellitus (IDDM)] and 23 normal controls (Con). Cycle ergometer exercise (55-60% of maximal O2 uptake) was performed until exhaustion. Glucose administration significantly increased endurance capacity in Con (112 +/- 7 vs. 125 +/- 6 min, P < 0.05) but only in IDDM patients whose blood glucose decreased during exercise (70.8 +/- 8.2 vs. 82.8 +/- 9.4 min, P < 0.05). Hyperglycemia was normalized at 15 min of exercise in Con (7.4 +/- 0.2 vs. 4.8 +/- 0.2 mM) but not in IDDM patients (12.4 +/- 0.7 vs. 15.6 +/- 0.9 mM). In Con, insulin and C-peptide levels were normalized during exercise. Glucose administration decreased growth hormone levels in both groups. In conclusion, oral glucose ingestion 30 min before exercise increases endurance capacity in Con and in some IDDM patients. In IDDM patients, in contrast with Con, exercise to exhaustion attenuates hyperglycemia but does not bring blood glucose levels to preglucose levels.
Authors:
P R Ramires; C L Forjaz; C M Strunz; M E Silva; J Diament; W Nicolau; B Liberman; C E Negrão
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  83     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-15     Completed Date:  1997-09-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  608-14     Citation Subset:  IM    
Affiliation:
Physical Education School, Endocrinology Unit, and Heart Institute, University of São Paulo 05508-900, Brazil. ramires@gandalf.physed.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Diabetes Mellitus, Type 1 / blood,  physiopathology*
Exercise
Glucose / pharmacology*
Hormones / blood
Humans
Physical Endurance / drug effects*
Pulmonary Gas Exchange / drug effects
Reference Values
Chemical
Reg. No./Substance:
0/Hormones; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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