| Oral fish oil restores striatal dopamine release after traumatic brain injury. | |
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MedLine Citation:
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PMID: 21514362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omega-3 fatty acid administration can affect the release of neurotransmitters and reduce inflammation and oxidative stress, but its use in traumatic brain injury (TBI) has not been described extensively. We investigated the effect of 7 day oral fish oil treatment in the recovery of potassium evoked dopamine release after TBI. Sham rats and TBI rats were given either olive oil or fish oil by oral gavage and were subject to cerebral microdialysis. Olive oil treated TBI rats showed significant dopamine release deficit compared to sham rats, and this deficit was restored with oral fish oil treatment. There was no effect of fish oil treatment on extracellular levels of dopamine metabolites such as 3,4-dihydroxyphenylacetic acid and homovanillic acid. These results suggest the therapeutic potential of omega-3 fatty acids in restoring dopamine neurotransmission deficits after TBI. |
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Authors:
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Samuel S Shin; C Edward Dixon |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-14 |
Journal Detail:
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Title: Neuroscience letters Volume: 496 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-16 Completed Date: 2011-09-07 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 168-71 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ireland Ltd. |
Affiliation:
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Brain Trauma Research Center, Department of Neurosurgery, University of Pittsburgh, 3434 Fifth Ave, Suite 201, Pittsburgh, PA 15260, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Analysis of Variance Animals Area Under Curve Brain Injuries / metabolism* Chromatography, High Pressure Liquid Corpus Striatum / drug effects, metabolism* Dopamine / metabolism* Extracellular Space / drug effects, metabolism Fatty Acids, Omega-3 / pharmacology Fish Oils / pharmacology* Homovanillic Acid / metabolism Male Potassium / pharmacology Rats Rats, Sprague-Dawley Stimulation, Chemical |
| Grant Support | |
ID/Acronym/Agency:
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1F30NS067731-01/NS/NINDS NIH HHS; 5R01NS060672-02/NS/NINDS NIH HHS; R01 NS060672-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fish Oils; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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