Document Detail

Oral fish oil restores striatal dopamine release after traumatic brain injury.
MedLine Citation:
PMID:  21514362     Owner:  NLM     Status:  MEDLINE    
Omega-3 fatty acid administration can affect the release of neurotransmitters and reduce inflammation and oxidative stress, but its use in traumatic brain injury (TBI) has not been described extensively. We investigated the effect of 7 day oral fish oil treatment in the recovery of potassium evoked dopamine release after TBI. Sham rats and TBI rats were given either olive oil or fish oil by oral gavage and were subject to cerebral microdialysis. Olive oil treated TBI rats showed significant dopamine release deficit compared to sham rats, and this deficit was restored with oral fish oil treatment. There was no effect of fish oil treatment on extracellular levels of dopamine metabolites such as 3,4-dihydroxyphenylacetic acid and homovanillic acid. These results suggest the therapeutic potential of omega-3 fatty acids in restoring dopamine neurotransmission deficits after TBI.
Samuel S Shin; C Edward Dixon
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-14
Journal Detail:
Title:  Neuroscience letters     Volume:  496     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-16     Completed Date:  2011-09-07     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  168-71     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ireland Ltd.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Analysis of Variance
Area Under Curve
Brain Injuries / metabolism*
Chromatography, High Pressure Liquid
Corpus Striatum / drug effects,  metabolism*
Dopamine / metabolism*
Extracellular Space / drug effects,  metabolism
Fatty Acids, Omega-3 / pharmacology
Fish Oils / pharmacology*
Homovanillic Acid / metabolism
Potassium / pharmacology
Rats, Sprague-Dawley
Stimulation, Chemical
Grant Support
1F30NS067731-01/NS/NINDS NIH HHS; 5R01NS060672-02/NS/NINDS NIH HHS; R01 NS060672/NS/NINDS NIH HHS
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fish Oils; 102-32-9/3,4-Dihydroxyphenylacetic Acid; RWP5GA015D/Potassium; VTD58H1Z2X/Dopamine; X77S6GMS36/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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