| Oral features in Apert syndrome: a histological investigation. | |
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MedLine Citation:
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PMID: 20078797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The number of publications on the oral features in Apert syndrome is limited. The present study investigated dental tissues in Apert syndrome histologically, to determine the nature and extent of anomalies, to provide some insight into the nature of the condition, and to explain how observed anomalies may affect the dental management of individuals with Apert syndrome. SETTING AND SAMPLE POPULATION: Extracted primary and secondary teeth were collected from patients with Apert who had attended the Australian Craniofacial Unit, Adelaide, South Australia. The total study sample comprised 13 individuals, aged from 14 to 21 , with nine men and four women. MATERIAL AND METHODS: A total of 40 teeth were available for histological examination (the number belonging to each individual varied from 2 to 5 per patient). The teeth were sectioned longitudinally, and one-half of each tooth underwent decalcification. Sections were stained with H&E for routine histological examination. Ground sections were prepared from undecalcified tooth halves. RESULTS: Histological assessment of the dental hard tissues revealed an intact enamel and dentinal structure but some irregularities were noted in the region of the dentino-enamel junction (DEJ), which could affect caries progression and also make dental management more difficult. CONCLUSION: This study identified histological anomalies of the DEJ of Apert syndrome teeth. An improved appreciation of the nature and extent of dental anomalies in Apert syndrome should assist clinicians when undertaking management of affected individuals. |
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Authors:
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T L Surman; R M Logan; G C Townsend; P J Anderson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Orthodontics & craniofacial research Volume: 13 ISSN: 1601-6343 ISO Abbreviation: Orthod Craniofac Res Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-18 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101144387 Medline TA: Orthod Craniofac Res Country: England |
Other Details:
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Languages: eng Pagination: 61-7 Citation Subset: D; IM |
Affiliation:
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School of Dentistry, Faculty of Health Sciences, The University of Adelaide, Adelaide, SA, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrocephalosyndactylia
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complications* Adolescent Dental Care for Disabled Dentin / abnormalities* Female Humans Male Receptors, Fibroblast Growth Factor / genetics Tooth Abnormalities / etiology* Tooth Cervix / abnormalities* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Fibroblast Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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