Document Detail


Oral etoposide following combination chemotherapy and radiation therapy in a patient with advanced adult neuroblastoma led to long survival.
MedLine Citation:
PMID:  11723749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although neuroblastoma is a common tumor of early childhood, it is rare in adults. In spite of the poor prognosis of advanced neuroblastoma in adults, there is still no effective treatment for this condition in adults. Here we report that oral etoposide salvage chemotherapy was able to prolong the survival of an adult patient with advanced neuroblastoma. A 26-year-old man had advanced neuroblastoma that was resistant to combination intravenous chemotherapy and radiation therapy. He was then treated with oral etoposide, at a dose of 50 mg daily for 5 days in a 21-day course. Toxicity was very mild and he was followed as an outpatient while he received 76 courses of this oral etoposide salvage chemotherapy. Seventy months after diagnosis, this patient is still alive and has no new distant metastases.
Authors:
S Yamaguchi; T Wada; K Oba; S Yoshihiro; K Naito
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of clinical oncology     Volume:  6     ISSN:  1341-9625     ISO Abbreviation:  Int. J. Clin. Oncol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-28     Completed Date:  2002-03-05     Revised Date:  2012-12-13    
Medline Journal Info:
Nlm Unique ID:  9616295     Medline TA:  Int J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  259-61     Citation Subset:  IM    
Affiliation:
Department of Urology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Antineoplastic Agents, Phytogenic / administration & dosage*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Etoposide / administration & dosage*
Humans
Male
Neuroblastoma / drug therapy*,  radiotherapy
Retroperitoneal Neoplasms / drug therapy*,  radiotherapy
Salvage Therapy*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 33419-42-0/Etoposide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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