Document Detail

Oral estrogen therapy may mitigate the effects of aerobic training on cardiorespiratory fitness in postmenopausal women: a double-blind, randomized clinical pilot study.
MedLine Citation:
PMID:  23942244     Owner:  NLM     Status:  Publisher    
OBJECTIVE: The aim of this study was to evaluate the isolated and associated effects of oral estrogen therapy and aerobic training on cardiorespiratory fitness in postmenopausal women.
METHODS: Forty-two hysterectomized healthy postmenopausal women were randomly divided (in a double-blind manner) into four groups: placebo-control (n = 9), estrogen therapy-control (n = 12), placebo-aerobic training (PLA-AT; n = 11), and estrogen therapy-aerobic training (ET-AT; n = 10). The estrogen therapy groups received estradiol valerate (1 mg/day) and the aerobic training groups trained on a cycle ergometer three times per week at moderate intensity. Before and 6 months after the interventions, all women underwent a maximal cardiopulmonary exercise test on a cycle ergometer.
RESULTS: Regardless of hormone therapy, aerobic training increased oxygen uptake at anaerobic threshold (P = 0.001), oxygen uptake at respiratory compensation point (P = 0.043), and oxygen uptake at peak exercise (P = 0.020). The increases at respiratory compensation point and peak exercise were significantly greater in the groups receiving placebo than in the groups receiving estrogen (oxygen uptake at respiratory compensation point: PLA-AT +5.3 [2.8] vs ET-AT +3.0 [2.5] mL kg min, P = 0.04; oxygen uptake at peak exercise: PLA-AT +5.8 [3.4] vs ET-AT +2.8 [1.4] mL kg min, P = 0.02).
CONCLUSIONS: Oral estrogen therapy may mitigate the cardiorespiratory fitness increase induced by aerobic training in hysterectomized healthy postmenopausal women.
Crivaldo Gomes Cardoso; Fábio Leandro Medina; Luiz Gustavo Pinto; Bruna Oneda; Luiz Augusto Riani Costa; Eliana Labes; Sandra Baliero Abrahão; Taís Tinucci; Décio Mion; Angela Maggio Fonseca; Cláudia Luica de Moraes Forjaz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-12
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  -     ISSN:  1530-0374     ISO Abbreviation:  Menopause     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the 1Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil; 2Center for Sport and Physical Education, State University of Londrina, Londrina, Brazil; and 3Gynecology and Climacteric Service and 4Hypertension Unit, General Hospital, University of São Paulo, São Paulo, Brazil.
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