Document Detail

Oral desensitization for food hypersensitivity.
MedLine Citation:
PMID:  21530825     Owner:  NLM     Status:  MEDLINE    
Food allergy has become an increasingly prevalent international health problem. Allergic reactions can result in life-threatening anaphylaxis in a short period of time, so the current standard of care dictates strict avoidance of suspected trigger foods and accessibility to injectable epinephrine. Intervention at the time of exposure is considered a rescue therapy rather than a disease-modifying treatment. Investigators have been studying allergen immunotherapy to promote induction of oral tolerance. This article examines the mechanisms of oral tolerance and the breakdown that leads to food allergy, as well as the history and current state of oral and sublingual immunotherapy development.
Michael H Land; Edwin H Kim; A Wesley Burks
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Immunology and allergy clinics of North America     Volume:  31     ISSN:  1557-8607     ISO Abbreviation:  Immunol Allergy Clin North Am     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8805635     Medline TA:  Immunol Allergy Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-76, xi     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Administration, Oral
Desensitization, Immunologic*
Food Hypersensitivity / immunology,  therapy*
Gastrointestinal Tract / immunology
Immune Tolerance / immunology
Mouth Mucosa / immunology
Treatment Outcome
Grant Support
5T32-AI007062-32/AI/NIAID NIH HHS; T32 AI007062/AI/NIAID NIH HHS; T32 AI007062-32/AI/NIAID NIH HHS

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