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Oral desensitisation in cow milk allergy: immunological findings.
MedLine Citation:
PMID:  12593788     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the literature there are several reports dealing with the possibility of a desensitising treatment in food allergy, but there are very few studies about the immunological mechanisms of oral desensitisation. We studied the immunological modifications in four children who underwent oral desensitisation with cow milk. Four children with cow milk allergy underwent oral desensitisation according to a standardized protocol. Total IgE, eosinophilic cationic protein in serum, and specific IgE and IgG4 to α-lactalbumin, to β-lactoglobulin and to casein were determined at the beginning of the treatment and after 6, 12 and 18 months in the 4 children treated. All the 4 treated patients successfully completed the treatment. Specific IgE to casein showed a significant reduction (p<0.01), while specific IgG4 to α-lactalbumin (p<0.02), to β-lactoglobulin (p<0.01) and to casein (p<0.01) showed a significant increase. Total IgE, eosinophilic cationic protein, and specific IgE to α-lactalbumin and to β-lactoglobulin did not show any significant modification. Control patients did not show any immunological modification and still had a positive double-blind, placebo-controlled food challenge. These results make us think that oral desensitisation in food allergy happens with the same mechanisms of traditional desensitising treatments for respiratory and insect sting allergies.
Authors:
G. Patriarca; A. Buonomo; C. Roncallo; M. Del Ninno; E. Pollastrini; A. Milani; T. De Pasquale; G. Gasbarrini; D. Schiavino; E. Nucera
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  15     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2002 Jan-Apr
Date Detail:
Created Date:  2003-Feb-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  53-58     Citation Subset:  -    
Affiliation:
Dept. Allergology, Catholic University, Policlinico A. Gemelli, Rome.
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