Document Detail

Oral contraceptives, tobacco smoking, and breast cancer risk.
MedLine Citation:
PMID:  2567919     Owner:  NLM     Status:  MEDLINE    
Findings from the United Kingdom's National Case-Control Study Group and an article by Miller et al fueled the long-standing controversy about the possible increase of the risk of breast cancer in young women after longterm use of oral contraceptives (OCs). Chance and hidden biases may be responsible for the diverging results between earlier studies and some recent case-control investigations. This addresses the new possibility that cigarette smoking increases cardiovascular risks associated with OCs but also reduces estrogens. Several estrogen-related diseases have been found to be negatively associated with tobacco smoking. A strong negative correlation between tobacco smoking and OC use is likely and it has been postulated that young girls who smoke heavily during their teenage years may have a lower frequency of breast cancer later on. If smoking does reduce breast cancer risk in young women this effect could confound the association between OCs and breast cancer risk. The authors state that even if there is a protective effect of smoking to early breast cancer the association would have no public health implications given the adverse effect of smoking on other health conditions.
D Trichopoulos; K Katsouyanni
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Publication Detail:
Type:  Comment; Letter    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-10     Completed Date:  1989-08-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  158     Citation Subset:  AIM; IM; J    
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MeSH Terms
Breast Neoplasms / etiology*
Contraceptives, Oral / adverse effects*
Risk Factors
Smoking / adverse effects*
Reg. No./Substance:
0/Contraceptives, Oral
Comment On:
Lancet. 1989 May 6;1(8645):1000   [PMID:  2565472 ]
Lancet. 1989 May 6;1(8645):973-82   [PMID:  2565515 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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