Document Detail


Oral contraceptives, exercise, and acute mountain sickness in women.
MedLine Citation:
PMID:  11506235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous research has found that exercise exacerbated acute mountain sickness (AMS) in men. PURPOSE: The current study tested this relationship in women taking oral contraceptives. METHODS: We studied seven women at 428 mmHg for 10 h; once while at rest (R) and once while performing intermittent exercise (EX). RESULTS: AMS scores had a slight increase at 9 vs. 0 h at altitude in both trials (p < 0.05). Resting measurements of ventilation (VE), arterial oxygen saturation (SPO2), end tidal O2 (PETO2), and end tidal CO2 (PETCO2) were not different over time or between trials (p > 0.05). While fluid intake did not change, urine output increased during the 0-3 h period, regardless of trial, and returned to baseline values by the 6-9 h period (218 +/- 37 vs. 121 +/- 22 ml x h(-1); p < 0.05). During exercise, SPO2 significantly dropped compared with similar time points in R (73.1 +/- 1.1 vs. 85.7 +/- 1.8%; p < 0.05). Despite exercise-induced desaturation, the AMS scores were not significantly different between R and EX. CONCLUSION: These results suggest that oral contraceptives may cause a compensation for the physiological responses to exercise critical for the development of AMS.
Authors:
D A Sandoval; D P Maes; L D'Acquisto; M Icenogle; R C Roach
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  72     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-16     Completed Date:  2001-12-20     Revised Date:  2010-07-29    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  733-8     Citation Subset:  IM; S    
Affiliation:
Central Washington University, Department of Physical Education, Health Education, and Leisure Services, Ellensburg, WA, USA. darleen.sandoval@mcmail.vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Altitude Sickness / chemically induced,  physiopathology*
Contraceptives, Oral / adverse effects,  pharmacology*
Exercise / physiology*
Female
Humans
Oxygen Consumption / drug effects
Pulmonary Ventilation / physiology
Respiration / drug effects
Urine
Water-Electrolyte Balance / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
HL07758/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Contraceptives, Oral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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