Document Detail

Oral contraceptives after intestinal bypass operations.
MedLine Citation:
PMID:  1036586     Owner:  NLM     Status:  MEDLINE    
A study was conducted on 7 fertile women (ages 19-44) after end-side jejunoileostomy for obesity. The peak plasma norethindrone (norethisterone) and levonorgestrel (formerly known as d-norgestrel) levels were measured during separate 24-hour norethindrone or levonorgestrel loads using conventional oral contraceptives (OCs). Compared to normal control patients, the intestinal bypass patients had severely reduced mean levels. The levels were 5.0 versus 20.8 ng/ml for norethindrone and the levels were 1.63 versus 4.25 ng/ml for levonorgestrel. Investigation of the patients' sex steroid binding globulin levels showed markedly reduced levels, implying a defective hepatic synthesis of this globulin rather than malabsorption as the most important factor. The data shows a reduced plasma level of OC in patients operated in this way, and OCs cannot be considered safe after intestinal bypass.
E D Johansson; J G Kral
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  JAMA     Volume:  236     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-01-28     Completed Date:  1977-01-28     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2847     Citation Subset:  AIM; IM; J    
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MeSH Terms
Contraceptives, Oral / adverse effects*,  metabolism
Ileum / surgery*
Jejunum / surgery*
Obesity / therapy*
Reg. No./Substance:
0/Contraceptives, Oral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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