Document Detail

Oral contraceptive use and exercise-induced muscle damage and recovery.
MedLine Citation:
PMID:  12169383     Owner:  NLM     Status:  MEDLINE    
Endogenous estrogen appears to attenuate muscle damage in animals; however, similar evidence in humans is not as strong. This investigation tested the hypothesis that women taking oral contraceptives, thereby having higher exogenous estrogen levels, would be more susceptible to damage or have an attenuated recovery from exercise-induced muscle damage. Muscle damage in women taking combined estrogen and progesterone oral contraceptives (OC) were compared to noncontraceptive users (NOC) after 50 eccentric muscle contractions of the elbow flexors. Measures of maximal isometric strength (MIS), range of motion (ROM), arm circumference (CIR), soreness (SOR), and serum creatine kinase (CK) activity were taken pre- and for 5 days post-exercise. All measures following exercises were similar between groups with the exception of MIS. Force recovery began 2 days post-exercise in the NOC group, while in the OC group strength did not start to return to normal until 4 days post-exercise (p < 0.05). Women taking oral contraceptives had a delayed strength recovery after eccentric exercise.
Kathleen J Savage; Priscilla M Clarkson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Contraception     Volume:  66     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-09     Completed Date:  2002-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Department of Exercise Science, University of Massachusetts, Amherst, MA, USA.
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MeSH Terms
Arm / anatomy & histology
Case-Control Studies
Contraceptives, Oral, Combined / adverse effects*
Muscle Fatigue
Muscle, Skeletal / injuries*,  physiology*
Range of Motion, Articular
Reg. No./Substance:
0/Contraceptives, Oral, Combined

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