Document Detail


Oral contraceptive treatment for rheumatoid arthritis: an open study in 10 female patients.
MedLine Citation:
PMID:  2684317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten female patients (median age 37 years, range 23-45) with active rheumatoid arthritis (RA) (nine seropositive, one seronegative, seven erosive, three non-erosive) were treated during 6 months with one of the earlier, i.e. higher dosed, oral contraceptives (Lyndiol, each tablet containing 2.5 mg lynestrenol and 0.05 mg ethinyloestradiol). None of the patients had been previously treated with a disease modifying drug. In one patient therapy with Lyndiol was stopped within 14 days after the start because of vomiting. Three out of the remaining nine patients stopped the therapy after 3 months because of inefficacy. Erythrocyte sedimentation rate (ESR) deteriorated during the study. Except for the number of swollen joints no clinical or laboratory parameters improved. We conclude that Lyndiol has no disease modifying effect in rheumatoid arthritis.
Authors:
J M Hazes; B A Dijkmans; J P Vandenbroucke; A Cats
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of rheumatology     Volume:  28 Suppl 1     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-22     Completed Date:  1989-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  28-30     Citation Subset:  AIM; IM; J    
Affiliation:
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arthritis, Rheumatoid / drug therapy*,  physiopathology
Clinical Trials as Topic
Contraceptives, Oral, Combined / therapeutic use
Edema / drug therapy,  physiopathology
Female
Humans
Joints / physiopathology
Lynestrenol / therapeutic use*
Mestranol / therapeutic use*
Middle Aged
Pain
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Contraceptives, Oral, Combined; 52-76-6/Lynestrenol; 72-33-3/Mestranol; 8015-14-3/Noracycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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