Document Detail

Oral contraceptive treatment for rheumatoid arthritis: an open study in 10 female patients.
MedLine Citation:
PMID:  2684317     Owner:  NLM     Status:  MEDLINE    
Ten female patients (median age 37 years, range 23-45) with active rheumatoid arthritis (RA) (nine seropositive, one seronegative, seven erosive, three non-erosive) were treated during 6 months with one of the earlier, i.e. higher dosed, oral contraceptives (Lyndiol, each tablet containing 2.5 mg lynestrenol and 0.05 mg ethinyloestradiol). None of the patients had been previously treated with a disease modifying drug. In one patient therapy with Lyndiol was stopped within 14 days after the start because of vomiting. Three out of the remaining nine patients stopped the therapy after 3 months because of inefficacy. Erythrocyte sedimentation rate (ESR) deteriorated during the study. Except for the number of swollen joints no clinical or laboratory parameters improved. We conclude that Lyndiol has no disease modifying effect in rheumatoid arthritis.
J M Hazes; B A Dijkmans; J P Vandenbroucke; A Cats
Related Documents :
23725927 - The effect of knee flexion contracture following total knee arthroplasty on the energy ...
10503557 - Cyclosporin and sulfasalazine combination in the treatment of early rheumatoid arthritis.
24638687 - Fondaparinux versus low molecular weight heparin following esophagectomy: results from ...
18414967 - Clinical impact of switching from infliximab to etanercept in patients with rheumatoid ...
21281257 - Development of simulated arthroscopic skills.
2214037 - Extraperitoneal endarterectomy for iliofemoral occlusive disease.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of rheumatology     Volume:  28 Suppl 1     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-22     Completed Date:  1989-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  28-30     Citation Subset:  AIM; IM; J    
Department of Rheumatology, University Hospital, Leiden, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arthritis, Rheumatoid / drug therapy*,  physiopathology
Clinical Trials as Topic
Contraceptives, Oral, Combined / therapeutic use
Edema / drug therapy,  physiopathology
Joints / physiopathology
Lynestrenol / therapeutic use*
Mestranol / therapeutic use*
Middle Aged
Severity of Illness Index
Reg. No./Substance:
0/Contraceptives, Oral, Combined; 52-76-6/Lynestrenol; 72-33-3/Mestranol; 8015-14-3/Noracycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Can oestrogens be used as adjuvant therapy in female patients with rheumatoid arthritis?
Next Document:  Oestrogen is a potent immunomodulator of murine experimental rheumatoid disease.