Document Detail


Oral contraceptive steroid induced platelet coagulant hyperactivity: dissociation of in vivo and in vitro effects.
MedLine Citation:
PMID:  3424284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of oral contraceptives (OC) has been associated with an increased risk of thromboembolic events in a subset of women. Factors predisposing to this problem are still not clearly defined although an increased platelet coagulant activity (CA) has been reported. This study was designed to evaluate the CA of platelets from asymptomatic current OC users compared with control subjects. The asymptomatic OC users were found to have evidence of hypercoagulability in the form of increased availability of platelet CA. These findings were present in both collagen stimulated and unstimulated platelets. In order to understand the mechanism we examined the in vitro effects of estradiol and/or progesterone on platelets. Platelets from normal males were incubated for one hour with estrogen and/or progesterone. There was no significant difference in CA of hormone treated platelets compared with control platelets from the same donor. CA was analyzed in platelets exposed to epinephrine, adenosine diphosphate, and collagen in the platelet aggregometer. Although a dose dependent effect was observed on CA of platelets exposed to the range of aggregating agents, the results show no significant difference between CA of the hormone treated and control platelets (p greater than 0.05). Likewise, platelet aggregation and release of nucleotide were not different between hormone treated and control platelets. Thus a direct effect of the hormones on platelets is an unlikely mechanism causing the increased CA seen in OC users.
Authors:
K M Huch; M B Elam; C M Chesney
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  48     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-02     Completed Date:  1988-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-50     Citation Subset:  IM; J    
Affiliation:
University of Tennessee, Memphis.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Coagulation / drug effects*
Blood Platelets / drug effects*,  metabolism,  physiology
Contraceptives, Oral / antagonists & inhibitors*
Epinephrine / pharmacology
Estradiol / pharmacology
Female
Humans
Male
Nucleotides / metabolism
Osmolar Concentration
Platelet Aggregation / drug effects
Progesterone / pharmacology
Reference Values
Steroids / adverse effects
Chemical
Reg. No./Substance:
0/Contraceptives, Oral; 0/Nucleotides; 0/Steroids; 50-28-2/Estradiol; 51-43-4/Epinephrine; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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