Document Detail

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease.
MedLine Citation:
PMID:  23036075     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic relapsing idiopathic disease. In clinical terms, most patients require lifelong medication associated with possible unpleasant adverse effects. Oral colon-specific drug delivery systems are designed to deliver therapeutic drugs to the inflamed colon to target pathophysiological manifestations of IBD. The aim is to maintain the drug with proper concentration in the inflamed colon, to enhance drug residence time and to minimize drug absorption by healthy tissues.
AREAS COVERED: This review addresses the main barriers for colon-specific drug delivery from organism, tissue and cell levels, respectively. It also summarizes novel colon-specific therapeutic strategies using microparticles and nanoparticles.
EXPERT OPINION: Oral colon-specific drug delivery represents a possible approach toward efficient treatment of IBD. As the environment of the gastrointestinal tract is harsh and intricate, this approach requires that drug carriers can respond to specific environmental factors of the inflamed colon, permitting stimulus-responsive release of loaded drugs to specific cells or even into specific organelles within cells.
Bo Xiao; Didier Merlin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-10-05
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  9     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-04-26     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  1393-407     Citation Subset:  IM    
Center for Diagnostics and Therapeutics, Department of Biology, Georgia State University, Atlanta, 30302, USA.
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MeSH Terms
Administration, Oral
Colon / drug effects*
Drug Carriers
Drug Delivery Systems*
Inflammatory Bowel Diseases / drug therapy*
Nanoparticles / administration & dosage
Pharmaceutical Preparations / administration & dosage
Grant Support
Reg. No./Substance:
0/Drug Carriers; 0/Pharmaceutical Preparations

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