Document Detail

Oral cholecystography: osmotic activity of iopanoic glucuronide in bile.
MedLine Citation:
PMID:  1160206     Owner:  NLM     Status:  MEDLINE    
The cholecystographic agent iopanoic acid (Telepaque) is excreted in high concentrations in the bile as the glucuronide, but produces little or no choleresis. In order to determine the osmotic characteristics of the excretory product, bile was collected from treated and untreated anesthetized dogs and the major solute concentrations and biliary osmolality were determined. After iopanoic acid, there was no change in biliary osmolality or in chloride or bicarbonate concentration. However, the calculated osmolality exceeded the measured osmolality to a significant degree. The data suggest that iopanoic glucuronide, like bile salts, is osmotically inactive because of micelle formation. From physiological considerations, low osmotic activity of the excreted contrast agent might enhance radiographic quality.
G H Mudge; W J Cooke
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Johns Hopkins medical journal     Volume:  137     ISSN:  0021-7263     ISO Abbreviation:  Johns Hopkins Med J     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0072456     Medline TA:  Johns Hopkins Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-8     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Bicarbonates / analysis
Bile / analysis*
Chlorides / analysis
Cholecystography / methods*
Glucuronates / analysis
Iopanoic Acid / administration & dosage,  analysis*
Osmolar Concentration
Reg. No./Substance:
0/Bicarbonates; 0/Chlorides; 0/Glucuronates; 96-83-3/Iopanoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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