Document Detail

Oral challenge with food additives.
MedLine Citation:
PMID:  3652696     Owner:  NLM     Status:  MEDLINE    
A randomized, placebo-controlled oral challenge with food additives (preservatives and food colorings) was carried out in 101 patients with eczema of undetermined origin who suspected that the intake of certain foods aggravated their dermatitis. 37 reacted to 1 or more of the food additives but not to a placebo, while 16 reacted to the placebo, or both the placebo and food additives. 48 had no reactions. The difference between the number of reactions to the food additives and the number of reactions to the placebo was not statistically significant. The reactions could be reproduced in only 1/3 of those challenged twice. It was not possible to correlate the reactions to food additives to reactivity to specific foodstuffs containing the same additives. If intolerance to food additives is suspected, an elimination diet seems warranted, regardless of whether the patient reacts to oral challenge with food additives.
N K Veien; T Hattel; O Justesen; A Nørholm
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Contact dermatitis     Volume:  17     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-11-20     Completed Date:  1987-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  100-3     Citation Subset:  IM    
Dermatology Clinic, Aalborg, Denmark.
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MeSH Terms
Administration, Oral
Double-Blind Method
Eczema / chemically induced*
Food Additives / adverse effects*
Reg. No./Substance:
0/Food Additives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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