Document Detail

Oral carcinoma in situ.
MedLine Citation:
PMID:  1054449     Owner:  NLM     Status:  MEDLINE    
Oral carcinoma in situ (CIS) as a histopathologic entity was studied in seventy-seven patients to determine the clinical and histologic parameters of the disease. There were forty-nine male and twenty-eight female patients, with 45.1 per cent of the lesions being described clinically as white, 15.9 per cent as red, and 8.5 per cent as a combination of the two. The high-risk sites for CIS were floor of the mouth (23.2 per cent of all lesions), tongue (22.0 per cent), and lips (in males only, 19.5 per cent). Histologically, there was a considerable range of variation in surface keratinization, thickness of epithelium, and certain cytologic alterations. The most consistent of all cytologic changes was loss of orientation of cells. There is no information available concerning possible regression of oral CIS, as is known for CIS of uterine cervix. Furthermore, there is no information concerning the frequency of or the period of transition from oral CIS to invasive carcinoma or whether all oral carcinoma is preceded by CIS. Further studies on this disease are essential.
C A Waldron; W G Shafer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, and oral pathology     Volume:  39     ISSN:  0030-4220     ISO Abbreviation:  Oral Surg. Oral Med. Oral Pathol.     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-05-28     Completed Date:  1975-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376406     Medline TA:  Oral Surg Oral Med Oral Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-38     Citation Subset:  D; IM    
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MeSH Terms
Carcinoma in Situ* / diagnosis,  epidemiology,  metabolism,  pathology
Cell Nucleus
Epithelial Cells
Keratins / metabolism
Lip Neoplasms / epidemiology
Middle Aged
Mouth Floor
Mouth Mucosa
Mouth Neoplasms* / diagnosis,  metabolism,  pathology
Palatal Neoplasms / epidemiology
Precancerous Conditions
Sex Factors
Tongue Neoplasms / epidemiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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