Document Detail

Oral candidiasis in patients receiving radiation therapy for head and neck cancer.
MedLine Citation:
PMID:  20647128     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate oral candidiasis in patients with head and neck cancer before, during, and after radiation therapy, and to explore its association with clinical oropharyngeal symptoms. STUDY DESIGN: A cohort study. SETTING: University hospital. SUBJECTS AND METHODS: Subjects who received radiation therapy (RT) for the treatment of head and neck cancer were divided into two groups: an oral cavity irradiated group (OIRR group, n = 29) and an oral cavity nonirradiated group (ONIRR group, n = 17). A control group consisted of 18 healthy subjects. Patients were examined for signs of oral candidiasis before, during, immediately after, and one month after RT. Mouth and throat soreness (MTS), dysphagia, and xerostomia were evaluated by self-reported questionnaires, and associations between oral candidiasis and these symptoms were analyzed. RESULTS: The incidence of oral candidiasis during RT was significantly higher in the OIRR group (55.2%) than in the ONIRR group (11.8%). Similarly, the occurrence of xerostomia during RT was significantly higher in the OIRR group (86.2%) than in the ONIRR group (52.9%). In the OIRR group, the mean MTS score at the 20th fraction of RT was significantly higher in patients with candidiasis (mean +/- SD, 5.8 +/- 2.1) than in those with RT-induced mucositis without candidiasis (3.7 +/- 2.0). In the OIRR group, 65.2 percent of patients who experienced dysphagia developed oral candidiasis, compared with only 10 percent in the ONIRR group. CONCLUSION: Oral candidiasis concurrent with oral mucositis due to RT may increase oropharyngeal discomfort during RT.
Zeyi Deng; Asanori Kiyuna; Masahiro Hasegawa; Isamu Nakasone; Atsushi Hosokawa; Mikio Suzuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  143     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  242-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
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MeSH Terms
Aged, 80 and over
Candidiasis, Oral / epidemiology,  etiology*
Case-Control Studies
Chi-Square Distribution
Head and Neck Neoplasms / radiotherapy*
Middle Aged
Prospective Studies
Risk Factors
Statistics, Nonparametric
Stomatitis / epidemiology,  etiology
Xerostomia / epidemiology,  etiology

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