| Oral candidiasis in patients receiving radiation therapy for head and neck cancer. | |
| | |
MedLine Citation:
|
PMID: 20647128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate oral candidiasis in patients with head and neck cancer before, during, and after radiation therapy, and to explore its association with clinical oropharyngeal symptoms. STUDY DESIGN: A cohort study. SETTING: University hospital. SUBJECTS AND METHODS: Subjects who received radiation therapy (RT) for the treatment of head and neck cancer were divided into two groups: an oral cavity irradiated group (OIRR group, n = 29) and an oral cavity nonirradiated group (ONIRR group, n = 17). A control group consisted of 18 healthy subjects. Patients were examined for signs of oral candidiasis before, during, immediately after, and one month after RT. Mouth and throat soreness (MTS), dysphagia, and xerostomia were evaluated by self-reported questionnaires, and associations between oral candidiasis and these symptoms were analyzed. RESULTS: The incidence of oral candidiasis during RT was significantly higher in the OIRR group (55.2%) than in the ONIRR group (11.8%). Similarly, the occurrence of xerostomia during RT was significantly higher in the OIRR group (86.2%) than in the ONIRR group (52.9%). In the OIRR group, the mean MTS score at the 20th fraction of RT was significantly higher in patients with candidiasis (mean +/- SD, 5.8 +/- 2.1) than in those with RT-induced mucositis without candidiasis (3.7 +/- 2.0). In the OIRR group, 65.2 percent of patients who experienced dysphagia developed oral candidiasis, compared with only 10 percent in the ONIRR group. CONCLUSION: Oral candidiasis concurrent with oral mucositis due to RT may increase oropharyngeal discomfort during RT. |
| | |
Authors:
|
Zeyi Deng; Asanori Kiyuna; Masahiro Hasegawa; Isamu Nakasone; Atsushi Hosokawa; Mikio Suzuki |
Related Documents
:
|
20231388 - Caspofungin use in patients with invasive candidiasis caused by common non-albicans can... 16908798 - Etiology and outcome of fever after a stay in the tropics. 2197908 - Fluconazole compared with amphotericin b plus flucytosine for cryptococcal meningitis i... 17642948 - Therapeutic trial of sodium antimony gluconate alone and in combination with ketoconazo... 19203518 - Cinacalcet reduces vascular and soft tissue calcification in secondary hyperparathyroid... 19847608 - Effect of combined treatment with sub-tenon injection of triamcinolone acetonide and ph... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 143 ISSN: 1097-6817 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-21 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 242-7 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. jordandzy@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Candidiasis, Oral / epidemiology, etiology* Case-Control Studies Chi-Square Distribution Female Head and Neck Neoplasms / radiotherapy* Humans Incidence Male Middle Aged Prospective Studies Questionnaires Risk Factors Statistics, Nonparametric Stomatitis / epidemiology, etiology Xerostomia / epidemiology, etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anatomic relationship between the spinal accessory nerve and internal jugular vein in the upper neck...
Next Document: Sleep apnea in patients with oral cavity and oropharyngeal cancer after surgery and chemoradiation t...