| Oral budesonide in the treatment of chronic refractory pouchitis. | |
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MedLine Citation:
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PMID: 17451569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pouchitis is the major long-term complication after ileal-pouch nal anastomosis for ulcerative colitis. Ten to 15% of patients develop a chronic pouchitis, either treatment responsive or treatment refractory. AIM: To evaluate the efficacy of oral budesonide in inducing remission and improving quality of life in patients with chronic refractory pouchitis. METHODS: Twenty consecutive patients with active pouchitis, not responding after 1 month of antibiotic treatment were treated with budesonide controlled ileal release 9 mg/day for 8 weeks. Symptomatic, endoscopic and histological evaluations were undertaken before and after treatment according to Pouchitis Disease Activity Index. Remission was defined as a combination of Pouchitis Disease Activity Index clinical score of < or = 2, endoscopic score of < or = 1 and total Pouchitis Disease Activity Index score of < or = 4. The quality of life was assessed with the Inflammatory Bowel Disease Questionnaire. RESULTS: Fifteen of 20 patients (75%) achieved remission. The median total Pouchitis Disease Activity Index scores before and after therapy were, respectively, 14 (range 9-16) and 3 (range 2-10) (P < 0.001). The median Inflammatory Bowel Disease Questionnaire score also significantly improved from 105 (range 77-175) to 180 (range 85-220) (P < 0.001). CONCLUSION: Eight-week treatment with oral budesonide appears effective in inducing remission in patients with active pouchitis refractory to antibiotic treatment in this open-label study. |
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Authors:
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P Gionchetti; F Rizzello; G Poggioli; F Pierangeli; S Laureti; C Morselli; R Tambasco; C Calabrese; M Campieri |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 25 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 1231-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy. paolo@med.unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Anti-Bacterial Agents / therapeutic use Anti-Infective Agents / administration & dosage* Budesonide / administration & dosage* Chronic Disease Colitis, Ulcerative / surgery Delayed-Action Preparations Female Humans Male Middle Aged Patient Compliance Pouchitis / drug therapy* Quality of Life / psychology* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Delayed-Action Preparations; 51333-22-3/Budesonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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