| Oral bowenoid lesions: differential diagnosis and pathogenetic insights. | |
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MedLine Citation:
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PMID: 11027384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine if oral lesions exhibiting bowenoid features reflect the diverse microscopic appearance and biologic behaviour of Bowen's disease and bowenoid papulosis of the skin and genitalia. STUDY DESIGN: Seven cases of oral bowenoid lesions (6 with follow-up data) were assessed for differences in histologic features, human papillomavirus (HPV) viral status, and selected immunohistochemically detectable cell cycling proteins (p53, WAF-1, Cyclin D1, Bcl-2) and were correlated with available follow-up data. RESULTS: Two histologic subsets were identified. One, which was believed to correspond to Bowen's disease, exhibited large numbers of transepithelial apoptotic bodies, dyskeratotic cells and mitoses (bowenoid elements), poor differentiation of background epithelial cells, and consistent HPV-16/18 positivity. The other, believed to correspond to bowenoid papulosis, exhibited few bowenoid elements, good background differentiation, and inconsistent HPV-16/18 positivity. One of the aggressive cases exhibited repeated recurrences despite apparent total clinical excision, whereas none of the other group recurred. CONCLUSION: Although a small number of cases are in this study, results suggest that oral bowenoid lesions may exhibit histopathologic and behavioral variations ranging from oral Bowen's disease to oral bowenoid papulosis. Studies on more cases are needed to confirm this initial impression. |
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Authors:
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T Daley; C Birek; G P Wysocki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 90 ISSN: 1079-2104 ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-17 Completed Date: 2000-11-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 466-73 Citation Subset: D; IM |
Affiliation:
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Department of Pathology, University of Western Ontario, London, Canada. tdaley@julian.uwo.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Apoptosis Bowen's Disease / chemistry, pathology*, virology Carcinoma in Situ / chemistry, pathology*, virology Cell Cycle Proteins / analysis DNA Probes, HPV / diagnostic use Diagnosis, Differential Humans Immunoenzyme Techniques Male Middle Aged Mouth Mucosa / chemistry, pathology, virology Mouth Neoplasms / chemistry, pathology*, virology Papillomaviridae / isolation & purification Skin Diseases, Papulosquamous / pathology*, virology |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/DNA Probes, HPV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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