Document Detail

Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome.
MedLine Citation:
PMID:  18795893     Owner:  NLM     Status:  MEDLINE    
Both antioxidant supplementation and exercise training have been identified as interventions which may reduce oxidative stress and thus improve cardiovascular health, but the interaction of these interventions on arterial BP (blood pressure) and vascular function has not been studied in older humans. Thus in six older (71+/-2 years) mildly hypertensive men, arterial BP was evaluated non-invasively at rest and during small muscle mass (knee-extensor) exercise with and without a pharmacological dose of oral antioxidants (vitamins C and E, and alpha-lipoic acid). The efficacy of the antioxidant intervention to decrease the plasma free radical concentration was verified via EPR (electron paramagnetic resonance) spectroscopy, while changes in endothelial function in response to exercise training and antioxidant administration were evaluated via FMD (flow-mediated vasodilation). Subjects were re-evaluated after a 6-week aerobic exercise training programme. Prior to training, acute antioxidant administration did not change resting arterial BP or FMD. Six weeks of knee-extensor exercise training reduced systolic BP (from 150+/-8 mmHg at pre-training to 138+/-3 mmHg at post-training) and diastolic BP (from 91+/-5 mmHg at pre-training to 79+/-3 mmHg at post-training), and improved FMD (1.5+/-1 to 4.9+/-1% for pre- and post-training respectively). However, antioxidant administration after exercise training negated these improvements, returning subjects to a hypertensive state and blunting training-induced improvements in FMD. In conclusion, the paradoxical effects of these interventions suggest a need for caution when exercise and acute antioxidant supplementation are combined in elderly mildly hypertensive individuals.
D Walter Wray; Abhimanyu Uberoi; Lesley Lawrenson; Damian M Bailey; Russell S Richardson
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  116     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-01-29     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-41     Citation Subset:  IM    
Department of Medicine, University of California La Jolla, 92093, USA.
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MeSH Terms
Antioxidants / administration & dosage,  adverse effects,  therapeutic use*
Blood Pressure / drug effects
Combined Modality Therapy
Cross-Over Studies
Dietary Supplements / adverse effects
Double-Blind Method
Drug Administration Schedule
Endothelium, Vascular / drug effects,  physiopathology
Exercise / physiology*
Free Radicals / blood
Hypertension / drug therapy*,  physiopathology,  rehabilitation
Treatment Outcome
Vasodilation / drug effects
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Free Radicals

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