Document Detail


Oral anticoagulants for stroke prevention in atrial fibrillation.
MedLine Citation:
PMID:  25194766     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The availability of 4 non-vitamin K oral anticoagulants (NOACs), that is, dabigatran, rivaroxaban, apixaban, and edoxaban, has changed the landscape of stroke prevention in patients with atrial fibrillation. This review article provides an overview of the 4 phase III studies that have compared these NOACs, examining major outcomes of efficacy and safety. A range of practical questions relating to the NOACs have emerged, including topics such as patient selection, treating patients with renal impairment, treating elderly patients, and combining anticoagulant therapy with antiplatelet drugs. We also address the interaction of various patient characteristics with the treatments and suggest the features can assist the physician in the choice of a particular NOAC for a particular patient(s).
Authors:
Keitaro Senoo; Deirdre A Lane; Gregory Y H Lip
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Publication Detail:
Type:  Journal Article     Date:  2014-07-17
Journal Detail:
Title:  Current problems in cardiology     Volume:  39     ISSN:  1535-6280     ISO Abbreviation:  Curr Probl Cardiol     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-09-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701802     Medline TA:  Curr Probl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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